高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (6): 1014.

• 研究论文 • 上一篇    下一篇

99mTcN(PNP5)(NOEt)]+新型心肌灌注显像剂研究

楚进锋1, 李彬2, 孔德靖2, 王学斌2, 张俊波2, 王金城3, 米宏志3, 赵建冬3   

  1. 1. 北京化工大学理学院, 北京100029;
    2. 北京师范大学化学系, 北京100875;
    3. 北京安贞医院核医学科, 北京100029
  • 收稿日期:2005-01-14 出版日期:2005-06-10 发布日期:2005-06-10
  • 通讯作者: 王学斌(1939年出生),男,教授,博士生导师,主要从事放射性药物化学研究.E-mail:xbwang@bnu.edu.cn E-mail:xbwang@bnu.edu.cn

Novel Potential Myocardial Perfusion Imaging Agent 99mTcN(PNP5)(NOEt)]+

CHU Jin-Feng1, LI Bin2, KONG De-Jing2, WANG Xue-Bin2, ZHANG Jun-Bo2, WANG Jin-Cheng3, MI Hong-Zhi3, ZHAO Jian-Dong3   

  1. 1. College of Science, Beijing University of Chemical Technology, Beijing 100029, China;
    2. Department of Chemistry, Beijing Normal University, Beijing 100875, China;
    3. Department of Nuclear Medicine, Beijing Anzhen Hospital, Beijing 100029, China
  • Received:2005-01-14 Online:2005-06-10 Published:2005-06-10

摘要: 以氯化亚锡为还原剂,SDH(丁二酰二酰肼)为供氮体,经配体交换反应得到[99mTcN(PNP5)·(NOEt)]+,通过TLC和HPLC分析,其放化纯度大于90%.该标记物是一种体外稳定性良好的阳离子配合物,在小鼠和狗体内的心肌初始摄取量高,滞留好,肝和肺等非靶组织清除快,有利于早期心肌显像,有望成为一种新型的心肌灌注显像剂.

关键词: 99mTc, 心肌灌注显像剂, 生物分布

Abstract: [99mTcN(PNP5)(NOEt)]+was prepared through ligand exchange reaction and its radiochemical purity was over 90% measured by TLC and HPLC. The results of charge character and stability studies indicate that [99mTcN(PNP5)(NOEt)]+ is a cation with a good stability. Studies on the biodistribution in mice and SPECT imaging in dog show that 99mTcN(PNP5)(NOEt)]+ possessed a high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent.

Key words: Technetium-99m, Myocardial perfusion imaging agent, Biodistribution

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