高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (12): 2227.

• 研究快报 • 上一篇    下一篇

中红外光纤光谱法用于甲状腺肿物的体表、 在体及离体检测研究

徐怡庄1,赵莹2,徐智3,杨丽敏4,刘玉峰1,凌晓锋3,张能维5,王立新3,王冰冰1,孟涛2,张元福1,翁诗甫1,周孝思3,徐端夫2,吴瑾光1   

  1. 1.北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京100871;
    2.中国科学院化学研究所,北京100080;3.北京大学第三医院,北京100083;
    4.北京大学物理学院重离子物理研究所,北京100871;5.北京铁路总医院,北京100038
  • 收稿日期:2005-08-01 出版日期:1905-03-14 发布日期:1905-03-14
  • 通讯作者: 徐怡庄(1967年出生),男,博士,副教授,从事分子光谱基础研究及其在材料科学和生命科学中的应用研究.E-mail:xyz@pku.edu.cn
  • 基金资助:

    国家重点基础研究发展规划项目(批准号:2002CCA01900)、国家自然科学基金(批准号:30371604,50203001)和教育部博士学科点基金资助.

Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy

XU Yi-Zhuang1*,ZHAO Ying2,XU Zhi3,YANG Li-Min4,LIU Yu-Feng1,LING Xiao-Feng3,ZHANG Neng-Wei5,WANG Li-Xin3,WANG Bing-Bing1,MENG Tao2,ZHANG Yuan-Fu1,WENG Shi-Fu1, ZHOU Xiao-Si3,XU Duan-Fu2,WU Jin-Guang1   

  1. 1. State Key Laboratory of Rare Earth Materials and Applications,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China; 2. Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080,China; 3. The Third Hospital,Peking University,Beijing 100083,China; 4. Institute of Heavy Ions,School of Physics,Peking University,Beijing 100871,China; 5. Beijing Railway General Hospital,Beijing 100038,China
  • Received:2005-08-01 Online:1905-03-14 Published:1905-03-14
  • Contact: XU Yi-Zhuang;E-mail:xyz@pku.edu.cn

被引次数

17

摘要：

本文对一些甲状腺患者的肿瘤组织分别进行了体表、术中在体和离体光谱检测研究,探讨了中红外光纤光谱法对甲状腺肿瘤进行无创体表检测的可能性,对术中红外光谱快速判断组织良恶性的规律性进行了系统研究.

关键词: FTIR;中红外光纤;甲状腺肿瘤;检测

Abstract:

In the present paper,FT-mid-IR fiber optics spectroscopy was used to determine the thyroid    tumor. A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work. Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients,in vivo detection and in vitro measurement of six patients in operation room was also carried out. The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination,the in vivo measurement and freshly resected thyroid tissues. The relative intensity and peak position of the IR bands in the region of 1 700-1 500 cm-1(amide Ⅰ and amide Ⅱ),1 480-1 400 cm-1,and 1 320-1 200 cm-1 are reliable spectral marker or indexes for tumor detection. These results demonstrate that FT-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.

Key words: FTIR; Mid-IR fiber optics; Thyroid tumor; Detection

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