高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (10): 1849-1851.

• 研究简报 • 上一篇    下一篇

聚苯乙烯负载的β-溴乙烯基硒化合物的合成及其在固相合成多取代烯烃中的应用

汤峨, 许建峰, 黄宪   

  1. 浙江大学西溪校区化学系, 杭州310028
  • 收稿日期:2004-11-05 出版日期:2005-10-10 发布日期:2005-10-10
  • 基金资助:

    国家自然科学基金(基金号:20272050);浙江省院士基金资助.

Synthesis of Polystyrene-supported Selenovinyl Bromide and Its Application in the Solid-phase Synthesis of Polysubstituted Olefins

TANG E, XU Jian-Feng, HUANG Xian   

  1. Department of Chemistry,Xixi Campus,Zhejiang University, Hangzhou 310028,China
  • Received:2004-11-05 Online:2005-10-10 Published:2005-10-10

关键词: &beta, -溴乙烯基硒化合物, 多取代烯烃, 固相合成

Abstract: Organoselenium reagents are powerful tools for the preparation of small organic molecules.A simple preparation of polystyrene-supported(E)-1-bromo-2-selenoethylene was reported.In the presence of NiCl2(PPh3)2 catalyst,polystyrene-supported(E)-1-bromo-2-selenoethylene reacted with different Grignard reagents to offer(E)-1,2-disubstituted ethenes or trisubstituted ethenes.The evident advantages of this reaction are easy operations,odorlessness,good yields of the products.

Key words: β-Selenovinyl bromide, Polysubstituted alkenes, Solid-phase synthesis

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