高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (10): 1817-1819.

• 研究论文 • 上一篇    下一篇

虎眼万年青单萜内酯新成分的分离及结构鉴定

白进发1,2, 刘志强1, 王淑敏1, 宋凤瑞1, 刘淑莹1   

  1. 1. 中国科学院长春应用化学研究所新药研究实验室,长春130022;
    2. 中国科学院研究生院,北京100039
  • 收稿日期:2004-09-29 出版日期:2005-10-10 发布日期:2005-10-10
  • 基金资助:

    国家自然科学基金(批准号:20173057);吉林省科技厅自然科学基金(批准号:20030916-2)资助

Isolation and Structure Identification of Novel Monoterpene Lactone from Ornithogalum Caudatum Ait

BAI Jin-Fa1,2, LIU Zhi-Qiang1, WANG Shu-Min1, SONG Feng-Rui1, LIU Shu-Ying1   

  1. 1. Laboratory of New Drug Research,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;
    2. Graduate School of the Chinese Academy of Sciences,Beijing 100039,China
  • Received:2004-09-29 Online:2005-10-10 Published:2005-10-10

摘要: 对虎眼万年青氯仿提取物进行柱层析分离,得到一种单萜内酯(Loliolide)化合物(6-羟基-4,4,7 a-三甲基-5,6,7,7 a-四氢-4H-苯并呋喃-2-酮),用红外光谱和核磁共振波谱确定了该化合物的结构,并用电喷雾多级串联质谱对化合物的裂解机理进行了研究.通过比旋光度和核磁共振氢谱确定了化合物的立体构型.

关键词: 虎眼万年青, 单萜内酯, 对映异构体

Abstract: A kind of monoterpene lactone,6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydro-4H-benzofuran-2-one,was isolated from Ornithogalum Caudatum Ait,whose structure was confirmed by IR and NMR methods,and its fragmentation pathway was studied by ESI-MSn.The stereo-structure of the compound was identified by the degree of specific rotation and 1H NMR.The experimental results demonstrate that the compound is firstly found in this kind of plant.

Key words: Ornithogalum caudatum Ait, Loliolide, Enantiomer

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