二乙三胺五乙酸二氢吡啶衍生物的合成及Gd(Ⅲ),Fe(Ⅲ),Mn(Ⅱ)配合物的弛豫性能研究

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (9): 1652.

二乙三胺五乙酸二氢吡啶衍生物的合成及Gd(Ⅲ),Fe(Ⅲ),Mn(Ⅱ)配合物的弛豫性能研究

郑书展, 简亚军, 白银娟, 解战峰, 常建华

西北大学化学系, 西安710069

收稿日期:2003-07-28 出版日期:2004-09-24 发布日期:2004-09-24
基金资助:
陕西省自然科学基金(批准号:2002B02)资助

Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid

ZHENG Shu-Zhan, JIAN Ya-Jun, BAI Yin-Juan, XIE Zhan-Feng, CHANG Jian-Hua

Department of Chemistry, Northwest University, Xi′an 710069, China

Received:2003-07-28 Online:2004-09-24 Published:2004-09-24

摘要/Abstract

摘要： 用二乙三胺五乙酸(DTPA)酸酐与二氢吡啶类化合物反应,合成了4种新型的含二氢吡啶基的二乙三胺五乙酸非离子型配体,并进一步合成了其Gd(Ⅲ),Fe(Ⅲ),Mn(Ⅱ)的顺磁性金属配合物.配体和配合物的结构用IR,¹HNMR及元素分析表征.研究了配合物的体外弛豫性能,结果表明,Fe(Ⅲ)和Mn(Ⅱ)配合物弛豫效率R₁ 低于Gd(Ⅲ)配合物的R₁ ,Gd(Ⅲ)配合物的弛豫效率较高,具有作为MRI造影剂的条件.

关键词: 二乙三胺五乙酸, 二氢吡啶, 磁共振成像造影剂, 弛豫效率

Abstract: Four novel ligands of DTPA-dihydropyridine derivatives which were designed for magnetic resonance imaging contrast agents were synthesized by the reaction between DTPA-dianhydride and 4-aniline-1,4-dihydropyridines. Their complexes of gadolinium, manganese and iron were prepared. Spin-lattice relaxivities(t₁) of the complexes was investigated. The results showed that all the complexes have relaxation effects on the protons in surrounding water molecules. The Gd(Ⅲ) complexes have higher relaxivities than those of Fe(Ⅲ) and Mn(Ⅱ) complexes. The NMR t₁ relaxivities(R₁) of Gd(Ⅲ)DTPA-dihydropyridines complexes are 5.50, 5.58, 5.20 and 5.49 L·mmol^-1·s^-1, which are higher than that of their parent complex, GdDTPA^2-. That indicating that the Gd(Ⅲ) complex possesses the precondition to be the contrast agents for magnetic resonance imaging.

Key words: Diethylenetriaminepentaacetic acid, Dihydropyridine, Magnetic resonance imaging contrast agent, Relaxivity

中图分类号:

O623.626

TrendMD:

郑书展, 简亚军, 白银娟, 解战峰, 常建华. 二乙三胺五乙酸二氢吡啶衍生物的合成及Gd(Ⅲ),Fe(Ⅲ),Mn(Ⅱ)配合物的弛豫性能研究. 高等学校化学学报, 2004, 25(9): 1652.

ZHENG Shu-Zhan, JIAN Ya-Jun, BAI Yin-Juan, XIE Zhan-Feng, CHANG Jian-Hua. Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid. Chem. J. Chinese Universities, 2004, 25(9): 1652.

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