几种新型苯甲酰基脲类几丁质抑制剂的合成(Ⅱ)

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (2): 294.

几种新型苯甲酰基脲类几丁质抑制剂的合成(Ⅱ)

徐蓉¹, 林军^1,2, 冒德寿¹, 严胜骄^1,2, 宗乾收¹, 杨丽娟^1,2, 刘复初¹

1. 云南大学应用化学系, 昆明 650091;
2. 南开大学元素有机化学国家重点实验室, 天津 300071

收稿日期:2002-12-02 出版日期:2004-02-24 发布日期:2004-02-24
通讯作者: 林　军(1960年出生),男,博士,教授,主要从事有机合成研究工作.E-mail;linjun@ynu.edu.cn E-mail:linjun@ynu.edu.cn
基金资助:
云南省自然科学基金(批准号;1999B0005M);南开大学元素有机化学国家重点实验室开发基金资助

Synthesis of Several Novel Benzoylurea Chitin Inhibitors(ê)

XU Rong¹, LIN Jun^1,2, MAO De-Shou¹, YAN Sheng-Jiao^1,2, ZONG Qian-Shou¹, YANG Li-Juan^1,2, LIU Fu-Chu¹

1. Department of Applied Chemistry, Yunnan University, Kunming 650091, China;
2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Received:2002-12-02 Online:2004-02-24 Published:2004-02-24

摘要/Abstract

关键词: 百菌清, 苯甲酰基脲, 几丁质合成抑制剂

Abstract: Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.

Key words: Chlorothaloni, Benzoylurea, Chitin inhibitor

中图分类号:

O625.632

TrendMD:

徐蓉, 林军, 冒德寿, 严胜骄, 宗乾收, 杨丽娟, 刘复初. 几种新型苯甲酰基脲类几丁质抑制剂的合成(Ⅱ). 高等学校化学学报, 2004, 25(2): 294.

XU Rong, LIN Jun, MAO De-Shou, YAN Sheng-Jiao, ZONG Qian-Shou, YANG Li-Juan, LIU Fu-Chu . Synthesis of Several Novel Benzoylurea Chitin Inhibitors(ê). Chem. J. Chinese Universities, 2004, 25(2): 294.