高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (10): 1849.

• 研究论文 • 上一篇    下一篇

四齿四棱草根部环肽化合物的分离及鉴定

窦辉1,2, 廖循2, 陈昌祥1, 彭树林2, 周燕2, 丁立生2   

  1. 1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 昆明650204;
    2. 中国科学院成都生物研究所, 成都610041
  • 收稿日期:2003-07-03 出版日期:2004-10-24 发布日期:2004-10-24
  • 基金资助:

    中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室(批准号:2002P12)资助

Isolation and Identification of Cyclopeptides from the Roots of Schnabelia tetradonta

DOU Hui1,2, LIAO Xun2, CHEN Chang-Xiang1, PENG Shu-Lin2, ZHOU Yan2, DING Li-Sheng2   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;
    2. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
  • Received:2003-07-03 Online:2004-10-24 Published:2004-10-24

摘要: 通过正相和反相硅胶柱层析,从四齿四棱草根部的乙醇提取物中分离纯化出4个环肽化合物,经波谱分析等鉴定了其结构,其中2个新化合物的结构分别为cyclo(-N-Pro1-Pro2-Phe1-Phe2-Leu1-Ser-Thr-Leu2-CO)(1,四棱草肽C)和cyclo(-N-Pro1-Pro2-His-Gly-Val-Asn-Ile-Trp-CO)(2,四棱草肽D).

关键词: 四齿四棱草, 环肽, 四棱草肽C, 四棱草肽D

Abstract: Four cyclopeptides were isolated from the roots of Schnabelia tetradonta, a Chinese endemic herb, through repeated column chromatography on normal and reversed phase silica gel. On the basis of spectroscopic and chemical evidence, the structures of two new cyclopeptides were elucidated as cyclo(N-Pro1-Pro2-Phe1-Phe2-Leu1-Ser-Thr-Leu2-CO)(1, schnabepeptide C) and cyclo(N-Pro1-Pro2-His-Gly-Val-Asn-Ile-Trp-CO)(2, schnabepeptide D), and other two cyclopeptides were schnabepeptide B(3) and schnabepeptide(4), respectively.

Key words: Schnabelia tetradonta, Cyclopeptide, Schnabepeptide C, Schnabepeptide D

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