高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (6): 1122.

• 论文 • 上一篇    下一篇

聚乙二醇-b-聚对苯二甲酸丁二醇酯嵌段共聚物降解行为的研究

张爱英, 冯增国, 张勇, 巴建华   

  1. 北京理工大学化工与材料学院, 北京 100081
  • 收稿日期:2002-04-10 出版日期:2003-06-24 发布日期:2003-06-24
  • 通讯作者: 冯增国(1957年出生),男,研究员,博士生导师,从事生物材料研究.E-mail:sainfeng@95777.com E-mail:sainfeng@95777.com
  • 基金资助:

    国家“八六三”计划(批准号:2001AA216077)资助

Studies on Degradation Behaviour of Poly(ethyleneglycol)-b-poly (butylene terephthalate) Copolymers

ZHANG Ai-Ying, FENG Zeng-Guo, ZHANG Yong, BA Jian-Hua   

  1. School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing 100081, China
  • Received:2002-04-10 Online:2003-06-24 Published:2003-06-24

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被引次数

13

摘要： 研究了系列PEG-b-PBT嵌段共聚物在pH=7.4磷酸盐缓冲溶液中和37℃条件下的体外降解行为.同时观察了水解降解过程中系列共聚物溶胀率、失重、特性粘度、结晶度和表面形态等方面的变化.实验结果表明,嵌段共聚物的组成直接影响其水解降解性能,共聚物的溶胀率和失重率随聚醚组分含量而增大;通过调节共聚物的组分比可以达到调节降解速率的目的.此外研究还表明,共聚物最初的降解主要发生在软段和硬段相联的酯键上.

关键词: PEG-b-PBT嵌段共聚物, 降解性能, 溶胀率, 特性粘度

Abstract: The degradation behavior of the copolymers are investigated by immersing the copolymer film into PBS(pH=7.4) at 37 ℃ in a shaking bath .The influence of the copolymer composition on physical properties, including the swelling ratio, the weight loss, the inherent viscosity, the surface morphology of polymer films, as well as the degree of crystallization is discussed. The experimental results reveal that the degradable profiles can be controlled by changing the copolymer composition.It is shown that the intial degradation of copolymer comes from the cleavage of the ester bonds between hydrophilic PEG and hydrophobic PBT.

Key words: PEG-b-PBT block copolymer, Degradation behavior, Swelling ratio, Inherent viscosity

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