高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (6): 1023.

• 论文 • 上一篇    下一篇

软珊瑚Sarcophyton crassocaule中Cembrane型二萜的分离与鉴定

徐效华1, 孔垂华2, 林长江1, 王昕1, 卢建华1   

  1. 1. 南开大学元素有机化学国家重点实验室, 天津 300071;
    2. 华南农业大学生态研究所, 广州 510642
  • 收稿日期:2002-05-13 出版日期:2003-06-24 发布日期:2003-06-24
  • 通讯作者: 徐效华(1964年出生),男,博士,教授,从事天然有机化学和药物化学的研究.E-mail:xxiaohua@public.tpt.t.jcn E-mail:xxiaohua@public.tpt.t.jcn

Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule

XU Xiao-Hua1, KONG Chui-Hua2, LIN Chang-Jiang1, WANG Xin1, LU Jian-Hua1   

  1. 1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
    2. Institute of Ecology, South China Agricultural University, Guangzhou 510642, China
  • Received:2002-05-13 Online:2003-06-24 Published:2003-06-24

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被引次数

8

摘要： 从采自中国南海西沙群岛海域的软珊瑚Sarcophytoncrassocaule中分离得到一种结构新颖的Cembrane型二萜,经1HNMR,13CNMR,HMQC,1H-1HCOSY,NOESY,FABMS和X射线晶体衍射确定其结构,命名为SarcocrassolideB它对P388的细胞毒性为1.5μg/mL.

关键词: 软珊瑚, Sarcophyton crassocaule, SarcocrassolideB

Abstract: A novel cembrane-type diterpenoid was first isolated from the soft coral Sarcophyton crassocaule collected from the Xisha Islands in the South China Sea. Its structure was determined on 2D-NMR, HRMASS and IR techniques and the relative configuration was confirmed by NOESY and X-ray diffraction. The crystaLIs monoclinic, space group P21 with cell dimensions of a=0.890 00(10) nm, b=0.638 0(10) nm, c=1.169 670(2) nm. α=90°, β=92.470(10)°, γ=90°, V=0.926(3) nm3, D=1.192 4 g/cm3, Z=2, R=0.057 8, wR=0.138 0. The new compound was named as Sarcocrassolide B. It exhibited a strong cytotoxicity against P388 cell line with IC50 value of 1.5 μg/mL.

Key words: Soft coral, Sarcophyton crassocaule, Sarcocrassolide B

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