高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (1): 73.

• 研究简报 • 上一篇    下一篇

辅酶NADH模型物还原反应动力学的核磁共振研究

李劲1, 刘有成1,3, 吴赛玉2, 夏静静1, 张家海2, 吴季辉2   

  1. 1. 中国科学技术大学化学系, 合肥 230026;
    2. 中国科学技术大学生物系, 合肥 230026;
    3. 兰州大学应用有机化学国家重点实验室, 兰州 730000
  • 收稿日期:2001-10-29 出版日期:2003-01-24 发布日期:2003-01-24
  • 通讯作者: 刘有成(1920年出生),男,博士,教授,中国科学院院士,从事物理有机化学研究.
  • 基金资助:

    国家自然科学基金(批准号:20072036,29832040);中国科学技术大学青年基金资助

A Kinetic NMR Study of Reduction Mechanism of NADH Models

LI Jing1, LIU You-Cheng1,3, WU Sai-Yu2, XIA Jing-Jing1, ZHANG Jia-Hai2, WU Ji-Hui2   

  1. 1. Department of Chemistry;
    2. Department of Biology, University of Science and Technology of China, Hefei 230026, China;
    3. National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2001-10-29 Online:2003-01-24 Published:2003-01-24

关键词: NADH模型, 动力学核磁共振, 负氢转移

Abstract: The rate constant and kinetic isotopic effect(kH/kD) of the reduction of 2-bromo-1-phenylethylidenemalononitrile with NADH model were determined through NMR spectroscopy. The results were consistent with that the hydride transfer step of the reaction which was the rate-determining step, and were comparable to the results obtained through UV-Vis Spectroscopy reported previously.

Key words: NADH models, Kinetic NMR, Hydride transfer

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