高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (8): 1352.

• 研究简报 • 上一篇    下一篇

龙葵醛的新合成方法研究

史真, 卢林刚, 王云侠   

  1. 西北大学化学系, 西安 710069
  • 收稿日期:2000-05-27 出版日期:2001-08-24 发布日期:2001-08-24
  • 通讯作者: 史真(1948年出生),男,教授,主要从事杂环化学新反应和有机合成新方法研究.E-mail:chemdir@nwu.edu.cn E-mail:chemdir@nwu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29872032);陕西省自然科学基金(批准号:FF982134)

A Novel Synthetic Method of Hydratropic Aldehyde

SHI Zhen, LU Lin-Gang, WANG Yun-Xia   

  1. Department of Chemistry, Northwest University, Xi'an 710069, China
  • Received:2000-05-27 Online:2001-08-24 Published:2001-08-24

关键词: 龙葵醛, 苯并咪唑盐, Grignard试剂, 有机合成

Abstract: Based on the one carbon unit transfer reaction of tetrahydrofolate coenzymes, hydratropic aldehyde was synthesized successfully by using benzimidazolium salt as tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transfered. Anovel method for the preparation of hydratropic aldehyde was provided. The mechanism for the addition-hydrolysis reaction of benzimidazolium salt with Grignard reagent and the effects of reaction condition on the yield are discussed.

Key words: Hydratropic aldehyde, Benzimidazolium salt, Grignard reagent, Organic syntheses

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