高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (8): 1332.

• 研究论文 • 上一篇    下一篇

脂肪酶催化作用下酰胺化反应的立体规则性研究

杨波1, 泉多惠子2, 张书圣1   

  1. 1. 青岛化工学院应用化学系, 青岛 266042;
    2. 日本山形大学工学部
  • 收稿日期:2000-06-12 出版日期:2001-08-24 发布日期:2001-08-24
  • 通讯作者: 张书圣(1966年出生),男,博士,教授,主要从事生物有机合成研究.
  • 基金资助:

    国家自然科学基金(批准号:29775012);山东省青年科学基金(批准号:Q99B16)

The Stereoselectivity of the Amidation Catalyzed by Lipase

YANG Bo1, IZUMI Taeko2, ZHANG Shu-Sheng1   

  1. 1. Department of Applied Chemistry, Qingdao Institute of Chemical Technology, Qingdao 266042, China;
    2. Division of Engineering, Yamagata University, Yonezawa, Yamagata 992_8510, Japan
  • Received:2000-06-12 Online:2001-08-24 Published:2001-08-24

PDF (PC)

被引次数

17

摘要： 提出了在LipasefromCandidaAntrarctica(CAL)脂肪酶的催化作用下,含有手性中心C原子的胺类化合物酰胺化的异构选择性规则.与氨基相连的碳原子的立体结构对酰胺化反应有很大的影响.型胺类化合物呈R-型优先选择,型胺类化合物呈S-型优先选择.

关键词: CAL(LipasefromCandidaAntrarctica)酶, 手性中心C原子, 酰胺化, 异构选择

Abstract: An empirical rule for amidation of amines which contains chiral carbon catalyzed by lipase from candida antrarctica has been proposed, anDIt is the same one as alcohols. It can be used to predict that which enantiomer reacts faster based on the relative sizes of the substituents at the stereocenter, but the recognization is very delicate to the structure of the carbon contacted with amino group. The R-enantiomer reacts faster when the amines are secondary amines; the Senantiomer reacts faster when they are primary amines.

Key words: Lipase from Candida Antrarctica(CAL), Chiral carbong, Amidation, Enantioselectivity

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