高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (1): 67.

• 研究论文 • 上一篇    下一篇

铜-(N-正十二碳酰双甘肽)配合物模拟SOD研究

谢英1, 周轩1, 王军波2, 李凤梅3, 邓希贤4   

  1. 1. 北京大学药学院, 北京 100083;
    2. 北京大学公共卫生学院, 北京 100083;
    3. 北京师范大学低能核物理研究所, 北京 100875;
    4. 北京师范大学化学系, 北京 100875
  • 收稿日期:2000-01-21 出版日期:2001-01-24 发布日期:2001-01-24
  • 通讯作者: 谢　英(1972年出生),女,硕士,讲师,主要从事模拟生物酶研究.E-mail:BMUxieying@sohu.com E-mail:BMUxieying@sohu.com
  • 基金资助:

    国家自然科学基金(批准号:29775015)资助

Studies on Imitation of SOD by N-Dodecanoyl-glycylglycinato-cuprate(Ⅱ)

XIE Ying1, ZHOU Xuan1, WANG Jun-Bo2, LI Feng-Mei3, DENG Xi-Xian4   

  1. 1. School of Pharmaceutical Science, Peking University, Beijing 100083, China;
    2. School of Public Health, Peking University, Beijing 100083, China;
    3. Institute of Low Energy Nuclear Physics, Beijing Normal Univrsity, Beijing 100875, China;
    4. Department of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2000-01-21 Online:2001-01-24 Published:2001-01-24

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被引次数

17

摘要： 合成一种新的SOD模拟物带功能基的长链铜()氨基酸配合物N-正十二碳酰双甘肽合铜[Cu(C12-Gly-Gly)]和二-(N-正十二碳酰双甘肽合铜)[Cu(C12-Gly-Gly)2].用脉冲辐解法测定了其SOD样活性,发现Cu(C12-Gly-Gly)2的SOD样活性基本接近于天然SOD,达到了整体模拟SOD的效果.

关键词: SOD模拟物, N-正十二碳酰双甘肽合铜, 脉冲辐解法

Abstract: Anew kind of analogues of SOD(N-dodecacyl-glycylglycinato)-cuprate(Ⅱ) [Cu(C12-Gly-Gly)] and di-[N-dodecacyl-glyglycinate-cuprate(Ⅱ)][Cu(C12-Gly-Gly)2] were prepared. Their SODlike activities were studied by using pulse radiolysis. It was found that the SODlike activity would be improved through adding long chain on Gly-Gly, and close to the natural SOD. The new complexes achieved to imitate SODas a whole.

Key words: Analogues of SOD, N-Dodecacyl-glycylglycinato-cuprate(Ⅱ), Pulse radiolysis

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