高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 52.

• Analytical Sciences • 上一篇    下一篇

Study of the Active Ingredients in Common Cold Medicines by Capillary Zone Electrophoresis with Amperometric Detection

ZHANG Lan1, HE Yu1, CHEN Guo-Nan1, FANG Yu-Zhi2   

  1. 1. Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002;
    2. Department of Chemistry, East China Normal University, Shanghai 200062
  • 出版日期:2000-12-31 发布日期:2000-12-31

Study of the Active Ingredients in Common Cold Medicines by Capillary Zone Electrophoresis with Amperometric Detection

ZHANG Lan1, HE Yu1, CHEN Guo-Nan1, FANG Yu-Zhi2   

  1. 1. Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002;
    2. Department of Chemistry, East China Normal University, Shanghai 200062
  • Online:2000-12-31 Published:2000-12-31

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摘要：

The patients of common cold and influenza usually have some uncomfortable symptoms, such as stuffy nose, runny nose, sneezing, coughing, headache and fever. Recently the new cold medicine often contains several components, and its comprehensive effect can decrease symptoms of cold. Pseudoephedrine hydrochloride (SDP), chlorphenamine maleas (CLM), caffeine (CAF) and paracetamol (PRC) are usually existed as combination in cold medicines:SDP as a vasoconstrictor for reducing nasal congestion, CLM as a cough suppressant, and CAF and PRC as an analgesia and antipyresis. Due to matrix effects and complex ingredients, it is very difficult to detect these four components mixture simultaneously. Capillary zone electrophoresis-amperometric detection (CZE-AD) offers a rapid, simple, sensitive, low cost and high separation method for determination of above mixture.

Abstract:

The patients of common cold and influenza usually have some uncomfortable symptoms, such as stuffy nose, runny nose, sneezing, coughing, headache and fever. Recently the new cold medicine often contains several components, and its comprehensive effect can decrease symptoms of cold. Pseudoephedrine hydrochloride (SDP), chlorphenamine maleas (CLM), caffeine (CAF) and paracetamol (PRC) are usually existed as combination in cold medicines:SDP as a vasoconstrictor for reducing nasal congestion, CLM as a cough suppressant, and CAF and PRC as an analgesia and antipyresis. Due to matrix effects and complex ingredients, it is very difficult to detect these four components mixture simultaneously. Capillary zone electrophoresis-amperometric detection (CZE-AD) offers a rapid, simple, sensitive, low cost and high separation method for determination of above mixture.

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