高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 53.
• Analytical Sciences • 上一篇 下一篇
WU Yi-Nan, PAN Yuan-Jiang, CHEN Yao-Zu
WU Yi-Nan, PAN Yuan-Jiang, CHEN Yao-Zu
摘要:
In our previous work, Reaction Mass Spectrometry (RMS) has been applied to determine the configuration of some enantiomers[1-4], by using some chiral organic compounds such as R, S-α-hydroxyphenylacetic acid, R, S-α-methoxyphenylacetic acid and R, S-phenylbutyric anhydride etc. as reaction reagents. As a continuation of this investigation, a pair of new asymmetric compounds (R)- and (S)-1, 1'-binaphthyl-2, 2'-diyl-methylphosphate (R, S-BNP ester) are used as stereoselective reagents. By comparison of the relative abundances of characteristic ions formed by reaction between the sample and the two enantiomers of the reagent, the configuration of the samples can be determined at the micromole level within a few minutes by reaction mass spectrometry.
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