高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 175.

• Chemistry in Life Sciences • 上一篇    下一篇

Study on the Interaction of Adriamycin to DNA

LI Wen-You1, XU Jin-Gou2   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071;
    2. Department of Chemistry, Xiamen University, Xiamen 361005
  • 出版日期:2000-12-31 发布日期:2000-12-31

Study on the Interaction of Adriamycin to DNA

LI Wen-You1, XU Jin-Gou2   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071;
    2. Department of Chemistry, Xiamen University, Xiamen 361005
  • Online:2000-12-31 Published:2000-12-31

摘要:

There has been considerable interest in understanding those factors that determine affinity and selectivity in binding of small molecules to DNA. These binding studies were driven partly by the need to understand the mechanism of anticancer drug action at the molecular level. The DNA binding studies with drugs have also provided a molecular basis to understand the binding and DNA sequence recognition by proteins.

Abstract:

There has been considerable interest in understanding those factors that determine affinity and selectivity in binding of small molecules to DNA. These binding studies were driven partly by the need to understand the mechanism of anticancer drug action at the molecular level. The DNA binding studies with drugs have also provided a molecular basis to understand the binding and DNA sequence recognition by proteins.

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