高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 174.

• Chemistry in Life Sciences • 上一篇    下一篇

Interaction Studies Between Peroxovanadium Complexes and Model Peptide in Active Center of Tyrosine Phosphatase

YE Jian-Liang, ZHOU Xing-Wang, CHEN Zhi-Wei, CHEN Zhong, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 362005
  • 出版日期:2000-12-31 发布日期:2000-12-31
  • 通讯作者: HUANG Pei-Qiang E-mail:pqhuang@jiangxian.xmu.edu.cn
  • 基金资助:

    This work was supported by the NNSF of China (No:29832020) and NNSF of Fujian province (No:C9910001)

Interaction Studies Between Peroxovanadium Complexes and Model Peptide in Active Center of Tyrosine Phosphatase

YE Jian-Liang, ZHOU Xing-Wang, CHEN Zhi-Wei, CHEN Zhong, HUANG Pei-Qiang   

  1. Department of Chemistry, Xiamen University, Xiamen 362005
  • Online:2000-12-31 Published:2000-12-31
  • Contact: HUANG Pei-Qiang E-mail:pqhuang@jiangxian.xmu.edu.cn
  • Supported by:

    This work was supported by the NNSF of China (No:29832020) and NNSF of Fujian province (No:C9910001)

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被引次数

17

摘要：

Peroxovanadium(pV) complexes are potent protein tyrosine phosphatase inhibitors and possibly could be developed into a new kind of oral drugs for treatment of diabetes[1,2]. They have been paid considerable attention nowadays. Their action mechanism of insulin-mimetic effects involved in irreversibly oxidizing the catalytic cysteine of the enzyme according to the latest evidence[3]. However, little was studied on the structure-function relationship of pV complexes until our latest paper[4] in which we suggested that it related to the interaction between pV and functional groups in active center of tyrosine phosphatase except for their oxidizing ability. In order to convince our assumption, histidine and glutathione with model functional groins of imidazole and sulfhydryl residue in the active domain of target enzyme[5] were selected as study object of interaction with pV complexes.

Abstract:

Peroxovanadium(pV) complexes are potent protein tyrosine phosphatase inhibitors and possibly could be developed into a new kind of oral drugs for treatment of diabetes[1,2]. They have been paid considerable attention nowadays. Their action mechanism of insulin-mimetic effects involved in irreversibly oxidizing the catalytic cysteine of the enzyme according to the latest evidence[3]. However, little was studied on the structure-function relationship of pV complexes until our latest paper[4] in which we suggested that it related to the interaction between pV and functional groups in active center of tyrosine phosphatase except for their oxidizing ability. In order to convince our assumption, histidine and glutathione with model functional groins of imidazole and sulfhydryl residue in the active domain of target enzyme[5] were selected as study object of interaction with pV complexes.

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