高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 159.

• Chemistry in Life Sciences • 上一篇    下一篇

Synthesis, Structural Characterization and Potentiometric Studies of Divalent Metal Complexes with Octadentate Tetraazamacrocyclic Ligand and Their DNA Cleavage Ability

KONG De-Yuan1, XIE Yu-Yuan2   

  1. 1. Department of Chemistry, TEXAS A & M university, College Station, TEXAS 77842-3012, USA;
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Taiyuan Road 294, Shanghai 200031
  • 出版日期:2000-12-31 发布日期:2000-12-31

Synthesis, Structural Characterization and Potentiometric Studies of Divalent Metal Complexes with Octadentate Tetraazamacrocyclic Ligand and Their DNA Cleavage Ability

KONG De-Yuan1, XIE Yu-Yuan2   

  1. 1. Department of Chemistry, TEXAS A & M university, College Station, TEXAS 77842-3012, USA;
    2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Taiyuan Road 294, Shanghai 200031
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Four new metal complexes with octadentate macrocyclic ligand[L=1,4,7,10-tetrakis(2-carbamoylethyl)-1,4,7, 10-tetraazacyclododecane] were synthesized and characterized by elemental analyses, IR and MS. These complexes have the general formula:M(L)(NO3)2·nH2O[M=Co(1), Ni(2), n=2; M=Cu(3), Zn(4), n=l]. The structures of complexes:(1), (2) and (3) have been determined by X-ray diffraction.[Co(L)(NO3)](NO3)]·2H2O (1) crystallizes in the triclinic space group P 1. The refinement converges with R=0.045 and Rw=0.057 for 3233 reflections with (I>2.5σ(I)). The Co has a octahedral geometry, was coordinated with four amine nitrogen atoms of macrocyclic ligand and two or one acylate oxygen atoms derived from amide pendant groups.[Ni(L)(NO3)](NO3)·2H2O (2) crystallizes in the monoclinic space group C2/c.

Abstract:

Four new metal complexes with octadentate macrocyclic ligand[L=1,4,7,10-tetrakis(2-carbamoylethyl)-1,4,7, 10-tetraazacyclododecane] were synthesized and characterized by elemental analyses, IR and MS. These complexes have the general formula:M(L)(NO3)2·nH2O[M=Co(1), Ni(2), n=2; M=Cu(3), Zn(4), n=l]. The structures of complexes:(1), (2) and (3) have been determined by X-ray diffraction.[Co(L)(NO3)](NO3)]·2H2O (1) crystallizes in the triclinic space group P 1. The refinement converges with R=0.045 and Rw=0.057 for 3233 reflections with (I>2.5σ(I)). The Co has a octahedral geometry, was coordinated with four amine nitrogen atoms of macrocyclic ligand and two or one acylate oxygen atoms derived from amide pendant groups.[Ni(L)(NO3)](NO3)·2H2O (2) crystallizes in the monoclinic space group C2/c.

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