高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (9): 1348.

• 论文 • 上一篇    下一篇

铜(Ê)与碘代酪氨酸和相关氨基酸混配配合物的圆二色谱研究──碘对甲状腺激素生物活性的结构作用探索

张锋, 宋溪明, 刘祁涛   

  1. 辽宁大学化学科学与工程学院, 沈阳 110036
  • 收稿日期:1999-11-03 出版日期:2000-09-24 发布日期:2000-09-24
  • 通讯作者: 张　锋(1961年出生),男,博士,教授,从事配位化学和生物无机化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29971014)资助

Circular Dichroism Study on Ternary Copper(Ê) Complexes with Diiodotyrosinates and Related Amino Acids An Approach to Structural Role of Iodine for Thyroid Hormone Activation

ZHANG Feng, SONG Xi-Ming, LIU Qi-Tao   

  1. Institute of Chemical Science and Engineering, Liaoning University, Shenyang 110036, China
  • Received:1999-11-03 Online:2000-09-24 Published:2000-09-24

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摘要： 用圆二色光谱法研究了铜(Ê)与3,5-二碘基-L-酪氨酸(L-I2tyr),L-酪氨酸(L-Tyr)或L-高丝氨酸(L-Hser)和L-/DL-AA[AA代表精氨酸(Arg),赖氨酸(Lys),天冬酰胺(Asn),谷氨酰胺(Gln),或丙氨酸(Ala)]三元混配配合物体系在不同离子强度(I=1.0或0.1mol/LKNO3)和溶剂环境[水,50%(体积分数)乙醇-水或50%(体积分数)二氧六环-水]条件下配合物分子内配体间相互作用.全部混配配合物的圆二色谱在599～623nm均有负的极大吸收,且Cu(L-I2tyr)(L-/DL-Arg)和Cu(L-I2tyr)(L-/DL-Lys)的$E异常负(-0.493～-1.072);Cu(L-I2tyr)(L-/DL-AA)的$E明显比Cu(L-Tyr)(L-/DL-AA)负.讨论了这些混配配合物中配体间相互作用的规律和碘的结构效应.

关键词: 碘代酪氨酸, 配体间相互作用, 混配配合物

Abstract: Circular dichroism (CD) spectra of the ternary copper(Ê) complexes with 3,5-diiodo-L-tyrosine (L-I2tyr), L-tyrosine (L-Tyr), or L-homoserine (L-Hser) and amino acids L-/DL-AA, where AArepresents arginine (Arg), lysine (Lys), asparagine (Asn), glutamine (Gln), or alanine (Ala), have been determined in the d-d region in various ionic strength (I=1.0 or 0.1 mol/L KNO3) and solvents(H2O, 50%(U)ethanol-H2O, or 50%(U)dioxane-H2O). The spectra exhibit a maximum at 599~623 nm for all the ternary complexes, and the $E for Cu(L-I2tyr)(L/DL-Arg) and Cu(L-I2tyr)(L/DL-Lys) are abnormally negative (-0.493~-1.072); the $E for Cu(L-I2tyr)(L/DL-AA) are obviously more negative than that for Cu(L-Tyr)(L/DL-AA). The possible ligand-ligand interactions in these ternary complexes were discussed, and the structural effects of the iodo groups on the interaction were emphasized.

Key words: Diiodotyrosine, Weak interaction among ligands, Ternary complex

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