高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (7): 1064.

• 研究简报 • 上一篇    下一篇

4β-氨基-4-脱氧鬼臼毒素和4β-氨基-4-脱氧-4'-去甲基鬼臼毒素的两种新合成方法

陈绍瑗1, 俞永平2, 游金宗2, 陈耀祖2,3   

  1. 1. 浙江大学生物系;
    2. 浙江大学化学系, 杭州 310027;
    3. 兰州大学应用有机化学国家重点实验室, 兰州 730000
  • 收稿日期:1999-06-07 出版日期:2000-07-24 发布日期:2000-07-24
  • 通讯作者: 陈耀祖(1927年出生),男,博士,教授,博士生导师,中国科学院院士,从事天然有机和有机分析研究.
  • 基金资助:

    国家新药研究基金(批准号:949503)资助

Two New Methods for Synthesis of 4β-Amino-4-deoxypodophyllotoxin and 4β-Amino-4'-demethyl-4-deoxypodophyllotoxin

CHEN Shao-Yuan1, YU Yong-Ping2, YOU Jin-Zong2, CHEN Yao-Zu2,3   

  1. 1. Departmentof Biology;
    2. Departmentof Chemistry, Zhejiang University, Hangzhou 310027;
    3. State Key Laboratory of App lied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:1999-06-07 Online:2000-07-24 Published:2000-07-24

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关键词: 鬼臼毒素, 二碘化钐, 甲酸铵

Abstract: Two new methods for synthesis of 4β-amino-4-deoxypodophyllotoxin and 4β-amino-4'-demethyl-4-deoxypodophyllotoxin have been developed. These compounds were synthesized by reduction of the corresponding4β-anzido-podophyllotoxin derivatives with SmI2 or HCO2NH4/Pd-Cin excellent yields under mild conditions with convenient manipulation.

Key words: Podophyllotoxin, Samarium diiodide, Ammonium formate

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