核酸分子“光开关”的研究进展

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (4): 527.

核酸分子“光开关”的研究进展

凌连生, 何治柯, 吴风武, 罗庆尧, 曾云鹗

武汉大学化学系, 武汉 430072

收稿日期:1999-07-12 出版日期:2000-04-24 发布日期:2000-04-24
通讯作者: 何治柯(1963年出生),男,博士,教授,主要从事分子光谱分析研究.
基金资助:
国家自然科学基金(批准号:29605001)

Progress of the Nucleic Acid Molecular “Light Switch”

LING Lian-Sheng, HE Zhi-Ke, WU Feng-Wu, LUO Qing-Yao, ZENG Yun-E

Department of Chemistry, Wuhan University, Wuhan 430072, China

Received:1999-07-12 Online:2000-04-24 Published:2000-04-24

摘要/Abstract

摘要： 综述了核酸分子“光开关”的发展及最新动态,阐述了它在核酸分子识别分析中的应用,并提出了研究核酸分子“光开关”的一些建议和看法.

关键词: 核酸分子识别, 核酸分子&ldquo, 光开关&rdquo, 插入键合, 电荷转移反应

Abstract: The progress of nucleic acid molecular “Light Switch” and DNAwas reviewed in this paper, which is obtained with ultraviolet absorption spectrum, fluoremetry, NMR, Tm and linear dicroism(LD), etc . The mechanism of fluorescence enhancement of molecular “Light Switch” by DNAand the charge transfer reaction between Ru(Ⅱ) and Rh(Ⅱ) are reported. It also describes the application of nucleic acid molecular “Light Switch” in sequence analysis, quantitative analysis of DNA, determination of c cm and detection of solvent polarity. The possible development of the nucleic acid molecular “Light Switch” is addressed.

Key words: Nucleic acid recognition, Nucleic acid molecular “Light Switch”, Intercalate binding, Charge transfer reaction

中图分类号:

Q523

TrendMD:

凌连生, 何治柯, 吴风武, 罗庆尧, 曾云鹗. 核酸分子“光开关”的研究进展. 高等学校化学学报, 2000, 21(4): 527.

LING Lian-Sheng, HE Zhi-Ke, WU Feng-Wu, LUO Qing-Yao, ZENG Yun-E . Progress of the Nucleic Acid Molecular “Light Switch”. Chem. J. Chinese Universities, 2000, 21(4): 527.