高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (3): 354.

• 论文 • 上一篇    下一篇

哺乳动物细胞光电行为的机理研究

张春阳, 慈云祥   

  1. 北京大学化学系, 北京 100871
  • 收稿日期:1999-05-08 出版日期:2000-03-24 发布日期:2000-03-24
  • 通讯作者: 慈云祥(1926年出生),男,教授,博士生导师,主要从事生化分析研究.
  • 基金资助:

    国家自然科学基金(批准号:39730160)

Theoretical Study on the Photoelectric Behavior of Mammalian Cells

ZHANG Chun-Yang, CI Yu-Xiang   

  1. Department of Chemistry, Peking University, Beijing 100871, China
  • Received:1999-05-08 Online:2000-03-24 Published:2000-03-24

PDF (PC)

被引次数

11

摘要： 研究了阿霉素、寡霉素和秋水仙素对细胞光电流的影响,发现细胞光电流的变化可适时表征药物对细胞的作用,且药物对细胞光电流的抑制率具有剂量和时间依赖性.据此提出了“光激励酶促反应加速模型”,并对哺乳动物细胞光电行为的机理进行了探讨.

关键词: 哺乳动物细胞, 光电行为, 光电流

Abstract: The effectiveness of doxorubicin, oligomycin and cholchicine on living cells was studied with the photoelectric method in this paper. The results indicated that the change of photoelectric current can reflect the effectiveness of drugs on living cells, and the inhibition effect of drugs on the photoelectric current of living cells was dependent on the drug concentration and drug-treating time. Based on these results, a model of “light-induced enzymatic-reaction acceleration” for the photoelectric behavior of mammalian cells had been proposed as well.

Key words: Mammalian cell, Photoelectric behavior, Photoelectric current

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