高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (12): 1820.

• 论文 • 上一篇    下一篇

新的醚链双生物碱尖叶唐松草阿原碱的结构测定

林翠梧1, 苏镜娱2, 曾陇梅2, 李红2, 彭文烈3, 徐安龙3   

  1. 1. 广西大学化学化工学院, 南宁 530004;
    2. 中山大学化学化工学院, 广州 510275;
    3. 中山大学生命科学学院, 广州 510275
  • 收稿日期:1999-10-25 出版日期:2000-12-24 发布日期:2000-12-24
  • 通讯作者: 苏镜娱(1930年出生),女,教授,博士生导师,主要从事天然有机化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29932030)资助

Structure Determination of a Novel Ether-linkaged Bisalkaloid Acutiaporberine

LIN Cui-Wu1, SU Jing-Yu2, ZENG Long-Mei2, LI Hong-PENG2, Wen-Lie3, XU An-Long3   

  1. 1. School of Chemistry and Chemical Engineering, Guangxi Univer sity, Nanning 530004, China;
    2. School of Chemistry and Chemical Engineering, Zhongshan University, Guang zhou 510275, China;
    3. School of Life Science, Zhong shan University, Guangz hou 510275, China
  • Received:1999-10-25 Online:2000-12-24 Published:2000-12-24

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被引次数

4

摘要： 从尖叶唐松草〔Thalictrumacutifolium(Hand.Mazz.)Boivin〕根分离得到一种新生物碱(尖叶唐松草阿原碱).通过IR,MS,1HNMR,13CNMR,2DNMR(包括1H-1HCOSY,13C-1HCOSY,NOESY和HMBC)测定了其化学结构,发现由阿朴菲和原小蘖碱通过醚链连接.对多种肿瘤细胞的生长有抑制作用,并有凋亡现象出现,而且对正常细胞的毒性较小

关键词: 尖叶唐松草, 醚链双生物碱, 阿朴菲, 原小蘖碱, 尖叶唐松草阿原碱(Ⅰ)

Abstract: Anovel ether linkaged bisalkaloid, acutiaporberine(Ⅰ) , was isolated from the root of Thalictrum acutifolium (Hand.Mazz.) Boivin.Its structure was determined by IR, MS, 1H NMR, 13C NMR, and2D NMR( 1H1HCOSY, 13C1H COSY, NOESY, and HMBC).Ether linkaged bisalkaloids, such as aporphine benzylisoguinoline type and bisbenzylisoquinoline type, have been found.Herein a novel type bisalkaloid composed of an aporphine and a protobebertine is reported for the first time.Compound Ⅰ can inhibit the growth of tumor cells and apoptosis can be seen.However, compound Ⅰ shows only slight toxic effects on normal soma cell lines

Key words: Thalictrum acutifolium (Hand.Mazz.) Boivin, Ether linkaged bisalkaloid, Aporphine, Protobebertine, Acutiaporberine(Ⅰ)

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