高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (1): 66.

• 论文 • 上一篇    下一篇

鬼臼毒素及其衍生物的单电子还原电位测定

汪世龙1, 王玫1, 孙晓宇1, 张超杰1, 马秀文1, 倪亚明1, 姚思德2, 王文峰2   

  1. 1. 同济大学测试中心, 上海 200092;
    2. 中国科学院上海原子核研究所辐射化学开放研究实验室, 上海 201800
  • 收稿日期:1999-03-26 出版日期:2000-01-24 发布日期:2000-01-24
  • 通讯作者: 汪世龙(1964年出生),男,博士,副教授,主要从事鬼臼毒素及其衍生物的治疗肿瘤机理研究.
  • 基金资助:

    国家自然科学基金(批准号:39700029)资助

Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

WANG Shi-Long1, WANG Mei1, SUN Xiao-Yu1, ZHANG Chao-Jie1, MA Xiu-Wen1, NI Ya-Ming1, YAO Si-De2, WANG Wen-Feng2   

  1. 1. Analysis and Research Centre of Tongji University, Shanghai 200092, China;
    2. Laboratory of Radiation Chemistry, Shanghai Instituteof Nuclear Research, Academia Sinica, Shanghai 201800, China
  • Received:1999-03-26 Online:2000-01-24 Published:2000-01-24

PDF (PC)

被引次数

7

摘要： 采用脉冲辐解技术,杜醌作参比物,通过改变鬼臼毒素、去甲表鬼臼毒素和VP-16的浓度,控制其阴离子向杜醌电子转移的速度,测得了鬼臼毒素、去甲表鬼臼毒素和VP-16的单电子还原电位分别为-310,-339和-334mV,揭示了鬼臼毒素及其衍生物作为抗肿瘤药物的辐射增敏机理.

关键词: 鬼臼毒素及其衍生物, 脉冲辐解, 单电子还原电位

Abstract: One-electron reduction potential is one of the important parameters of radiosensitive compound with a high electron affinity. In this work one-electron reduction potentials of podophyllotoxin and its derivatives were determined by pulse radiolysis using duroquinone as references. The one-electron reduction potentials of podophyllotoxin, 4'-demethylepipodophyllotoxin(DMEP) and etoposide (VP-16) are -310 mV, -339 mV, -334 mV, respectively.

Key words: Podophyllotoxin and its derivative, Pulse radiolysis, One-electron reduction potential

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