高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 585.

• Teaching and Education in Analytical Chemistry;NMR;Others • 上一篇    

Solvating Agent Optimization in the Determination of Chiral Drug Purity and Absolute Configuration by 1HNMR Spectroscopy

George Hanna   

  1. Northeast Regional Laboratory, ORA, FDA, 850 Third Ave., Brooklyn, NY 11232, USA
  • 出版日期:1999-12-31 发布日期:1999-12-31

Solvating Agent Optimization in the Determination of Chiral Drug Purity and Absolute Configuration by 1HNMR Spectroscopy

George Hanna   

  1. Northeast Regional Laboratory, ORA, FDA, 850 Third Ave., Brooklyn, NY 11232, USA
  • Online:1999-12-31 Published:1999-12-31

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摘要：

High-field lH NMR methodology for purity determination of the β-blocker drugs utilizing solvating agent is presented. Optimal experimental conditions for the resolution of the signals were determined by studying the interaction of substrate concentration, solvating agent concentration and temperature.

Abstract:

High-field lH NMR methodology for purity determination of the β-blocker drugs utilizing solvating agent is presented. Optimal experimental conditions for the resolution of the signals were determined by studying the interaction of substrate concentration, solvating agent concentration and temperature.

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