高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 507.

• Biological Analysis • 上一篇    下一篇

Circular Dichroism Study on Interaction between Adriamycin and DNA as well as Effect of Metal Ions

FANG Yu-Zhi, HE Pin-Gang, FENG Min   

  1. Department of Chemistry, East China Normal University, Shanghai, 200062, China
  • 出版日期:1999-12-31 发布日期:1999-12-31

Circular Dichroism Study on Interaction between Adriamycin and DNA as well as Effect of Metal Ions

FANG Yu-Zhi, HE Pin-Gang, FENG Min   

  1. Department of Chemistry, East China Normal University, Shanghai, 200062, China
  • Online:1999-12-31 Published:1999-12-31

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摘要：

Adriamycin (ADM) is an anthracycline antibiotic with highly antineoplastic activity which has been in wide clinical use for treatment of various types of cancers. A variety of biochemical evidence suggests that adriamycin function primarily at the DNA level by blocking the processes of replication and transcription. A number of papers have reported that metal ion affects the drug's activity.

Abstract:

Adriamycin (ADM) is an anthracycline antibiotic with highly antineoplastic activity which has been in wide clinical use for treatment of various types of cancers. A variety of biochemical evidence suggests that adriamycin function primarily at the DNA level by blocking the processes of replication and transcription. A number of papers have reported that metal ion affects the drug's activity.

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