高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 488.

• Biological Analysis • 上一篇    下一篇

Piezoelectric Genosensor Based on PCR Amplification and Application to Detection of Human Papillomavirus Oncogene

MO Zhi-Hong, LIU Jian-Hui, XUE Qiang, FU Wei-Ling   

  1. 1. Department of Applied Chemistry, Chongqing University, Chongqing, 400044, PR China;
    2. Medical Laboratory, Southwestern Hospital, Third Military Medical University, Chongqing, 400038, PR China
  • 出版日期:1999-12-31 发布日期:1999-12-31
  • 基金资助:

    supported by the National Natural Science Foundation of China (No.39870831).

Piezoelectric Genosensor Based on PCR Amplification and Application to Detection of Human Papillomavirus Oncogene

MO Zhi-Hong, LIU Jian-Hui, XUE Qiang, FU Wei-Ling   

  1. 1. Department of Applied Chemistry, Chongqing University, Chongqing, 400044, PR China;
    2. Medical Laboratory, Southwestern Hospital, Third Military Medical University, Chongqing, 400038, PR China
  • Online:1999-12-31 Published:1999-12-31
  • Supported by:

    supported by the National Natural Science Foundation of China (No.39870831).

PDF (PC)

被引次数

10

摘要：

This report presents a new concept of genosensor based on polymerase chain reaction (PCR) amplification with in-situ piezoelectric micro-mass measurement. Though there are increasing reports on DNA hybridization sensors based on electrochemical, optical and piezoelectric transducers with advantages such as simplicity and cost-effectiveness, the sensitivity of genosensors developed so far could not match with the PCR technique, which is well-known to be generated in abundance.

Abstract:

This report presents a new concept of genosensor based on polymerase chain reaction (PCR) amplification with in-situ piezoelectric micro-mass measurement. Though there are increasing reports on DNA hybridization sensors based on electrochemical, optical and piezoelectric transducers with advantages such as simplicity and cost-effectiveness, the sensitivity of genosensors developed so far could not match with the PCR technique, which is well-known to be generated in abundance.

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