高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 347.

• Molecular Spectroscopy • 上一篇    下一篇

The Theoretic Study on UV Bands of DNA Adducts from syn-Dibenzo[a,l]Pyrene Dieolepoxide with Different Conformations

ZHOU Zhi-Gang, DAI Qian-Huan, WANG Dian-Zuo   

  1. 1. The Center of Environmental Science, Peking University, Beijing, 100871, P. R. China;
    2. Center of Cancer Chemi. & Bio. Eng., Beijing, 100022, P. R. China
  • 出版日期:1999-12-31 发布日期:1999-12-31

The Theoretic Study on UV Bands of DNA Adducts from syn-Dibenzo[a,l]Pyrene Dieolepoxide with Different Conformations

ZHOU Zhi-Gang, DAI Qian-Huan, WANG Dian-Zuo   

  1. 1. The Center of Environmental Science, Peking University, Beijing, 100871, P. R. China;
    2. Center of Cancer Chemi. & Bio. Eng., Beijing, 100022, P. R. China
  • Online:1999-12-31 Published:1999-12-31

PDF (PC)

摘要：

The low-temperature fluorescence spectroscopy(LTFS) and fluorescence line-narrowing spectroscopy(FLNS) are useful tool to study the DNA adducts from various PAHs. The results of analysis on DNA adducts of metabolites of carcinogenic agents suggested that the existence of multiple conformations. It is believed that the conformation of DNA adducts is important to its carcinogenesis. So we theoretically computed the wavelength of the DNA adducts and study the conformations of the adducts together with experimental results try to know the relationship of conformations of adducts and its genotoxity.

Abstract:

The low-temperature fluorescence spectroscopy(LTFS) and fluorescence line-narrowing spectroscopy(FLNS) are useful tool to study the DNA adducts from various PAHs. The results of analysis on DNA adducts of metabolites of carcinogenic agents suggested that the existence of multiple conformations. It is believed that the conformation of DNA adducts is important to its carcinogenesis. So we theoretically computed the wavelength of the DNA adducts and study the conformations of the adducts together with experimental results try to know the relationship of conformations of adducts and its genotoxity.

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