高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 286.

• Chromatography and Separation Sciences • 上一篇    下一篇

Chiral Separations of Five Organic Catalysts by Cyclodextrin-modified Capillary Zone Electrophoresis

ZHANG Xin-Xiang, HONG Feng, CHANG Wen-Bao, Cl Yun-Xiang, LI Yue-Lan, GUAN Ye-Di   

  1. Department of Chemistry, Peking University, Beijing, 100871, China
  • 出版日期:1999-12-31 发布日期:1999-12-31
  • 基金资助:

    Supported by the National Natural Science Foundation of China(29305035) and SRFROCS from State Education Ministry.

Chiral Separations of Five Organic Catalysts by Cyclodextrin-modified Capillary Zone Electrophoresis

ZHANG Xin-Xiang, HONG Feng, CHANG Wen-Bao, Cl Yun-Xiang, LI Yue-Lan, GUAN Ye-Di   

  1. Department of Chemistry, Peking University, Beijing, 100871, China
  • Online:1999-12-31 Published:1999-12-31
  • Supported by:

    Supported by the National Natural Science Foundation of China(29305035) and SRFROCS from State Education Ministry.

PDF (PC)

摘要：

Chiral separation is very important and become a significant task of analytical chemistry in many fields. Capillary electrophoresis (CE) is a technique undergoing rapid development for chiral separation at the present time. With its high efficiency, simple operation, and extremely small sample volume,CE has become a powerful tool for chiral separation. There are many chiral selectors, such as cyclodextrins (CDs), proteins, chiral surfactants, antibiotics, bile salts, using in CE chiral separation. CDs has been most wildly used in them. Cyclodextrin (CD) is a cyclic sugar made of certain glucose units in which each has 5 chiral centers and it shows the shape of cavity with a big end and a small end. The inside of CD is hydrophobic and the outside is hydrophilic. The chiral selectivity of CD comes from the formation of host-guest compound between CD and analytes. The differences of the hydrogen-bond and the other interactions between CD and two enantiomers cause enantio-selectivity.

Abstract:

Chiral separation is very important and become a significant task of analytical chemistry in many fields. Capillary electrophoresis (CE) is a technique undergoing rapid development for chiral separation at the present time. With its high efficiency, simple operation, and extremely small sample volume,CE has become a powerful tool for chiral separation. There are many chiral selectors, such as cyclodextrins (CDs), proteins, chiral surfactants, antibiotics, bile salts, using in CE chiral separation. CDs has been most wildly used in them. Cyclodextrin (CD) is a cyclic sugar made of certain glucose units in which each has 5 chiral centers and it shows the shape of cavity with a big end and a small end. The inside of CD is hydrophobic and the outside is hydrophilic. The chiral selectivity of CD comes from the formation of host-guest compound between CD and analytes. The differences of the hydrogen-bond and the other interactions between CD and two enantiomers cause enantio-selectivity.

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