高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 240.

• Chromatography and Separation Sciences • 上一篇    下一篇

Enantioseparation of α-Amino Acids by Capillary Electrophoresis Using L-Cysteine-Modified Cyclodextrins as Chiral Selectors

JIN Yang, Naoyoshi Egashira, Takanori Inoue, Yoshiaki Kurauchi, Kazuya Ohga   

  1. Department of Applied Chemistry, Faculty of Engineering, Oita University, Dannoharu, Oita 870-1192, Japan
  • 出版日期:1999-12-31 发布日期:1999-12-31

Enantioseparation of α-Amino Acids by Capillary Electrophoresis Using L-Cysteine-Modified Cyclodextrins as Chiral Selectors

JIN Yang, Naoyoshi Egashira, Takanori Inoue, Yoshiaki Kurauchi, Kazuya Ohga   

  1. Department of Applied Chemistry, Faculty of Engineering, Oita University, Dannoharu, Oita 870-1192, Japan
  • Online:1999-12-31 Published:1999-12-31

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摘要：

Capillary electrophoresis (CE) is a powerful separation technique that was used in a wide range of analytical chemical applications. Cyclodextrins(CDs) are the most commonly used chiral selectors in chiral capillary electrophoresis at the present time. Under neutral conditions, however, native CDs are neutral and usually applicable only for the enantioseparation of charged analyses. To overcome this defect we modified α- and β-CD with a L-cysteine moiety and used the CD derivatives as chiral selectors for the separation of a-amino acid enantiomers by the ligand exchange mode.

Abstract:

Capillary electrophoresis (CE) is a powerful separation technique that was used in a wide range of analytical chemical applications. Cyclodextrins(CDs) are the most commonly used chiral selectors in chiral capillary electrophoresis at the present time. Under neutral conditions, however, native CDs are neutral and usually applicable only for the enantioseparation of charged analyses. To overcome this defect we modified α- and β-CD with a L-cysteine moiety and used the CD derivatives as chiral selectors for the separation of a-amino acid enantiomers by the ligand exchange mode.

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