高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (S1): 135.

• Electroanalytical Chemistry • 上一篇    下一篇

Determination of Captopril by Single Sweep Oscillopolarography

ZHONG Shui-Zhen, WU Ying, SHI Xiao-Hong   

  1. College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China
  • 出版日期:1999-12-31 发布日期:1999-12-31

Determination of Captopril by Single Sweep Oscillopolarography

ZHONG Shui-Zhen, WU Ying, SHI Xiao-Hong   

  1. College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China
  • Online:1999-12-31 Published:1999-12-31

摘要:

Captopril (CPT)(l-[2(s)-3-mercapto-2-methyl-l-oxopropyl]-L-proline) is an angiotensin converting-enzyme inhibitor. It has been reported that CPT can be determined by liquid chrornatography, Ultra-violet spectrophotometry, and gas chromatographic-mass spectrometry. In this paper the polarographic behavior of CPT were studied on a JP-2 oscillopolarograph and a BAS-100A Electrochemical Analyzer. A sensitive analytical method of CPT is obtained. It has been applied to quantitative analysis of CPT tablet with satisfying results.

Abstract:

Captopril (CPT)(l-[2(s)-3-mercapto-2-methyl-l-oxopropyl]-L-proline) is an angiotensin converting-enzyme inhibitor. It has been reported that CPT can be determined by liquid chrornatography, Ultra-violet spectrophotometry, and gas chromatographic-mass spectrometry. In this paper the polarographic behavior of CPT were studied on a JP-2 oscillopolarograph and a BAS-100A Electrochemical Analyzer. A sensitive analytical method of CPT is obtained. It has been applied to quantitative analysis of CPT tablet with satisfying results.

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