高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (6): 990.

• 研究简报 • 上一篇    下一篇

主链含己烷雌酚的聚酸酐的合成及其降解性能研究

周传军, 范昌烈, 胡运华, 卓仁禧   

  1. 武汉大学化学学院, 武汉 430072
  • 收稿日期:1998-06-30 出版日期:1999-06-24 发布日期:1999-06-24
  • 通讯作者: 范昌烈
  • 作者简介:周传军,男,26岁,硕士研究生.
  • 基金资助:

    湖北省自然科学基金

Studies on Synthesis and Degradation Properties of Polyanhydrides with HexestroLIN the Backbone

ZHOU Chuan-Jun, FAN Chang-Lie, HU Yun-Hua, ZHUO Ren-Xi   

  1. College of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1998-06-30 Online:1999-06-24 Published:1999-06-24

PDF (PC)

被引次数

15

摘要： 聚酸酐是一类新型的药物控制释放载体材料,具有良好的生物相容性和表面溶蚀性能[1].聚酸酐的降解和药物释放速率可通过改变单体结构、共聚物的组成和主链上的酸酐键密度实现.后者主要是把降解速率不同的酯键、酰(亚)胺键和磷酸酯键引入主链上.

关键词: 聚合物控制药物释放体系, 聚酯酸酐, 熔融缩聚, 己烷雌酚

Abstract: Polymeric drug containing active agent in the backbone was one of the controlled release systems. In this paper, some polymers, which have an antineoplastic agent(hexestrol) in the backbone, have been synthesized by copolymerization hexestrol bis(hydrogen succinate) with sebacic acid(SA). Hexestrol bis(hydrogen succinate) was prepared by reaction hexestrol with succinic anhydride. The degradation properties in vitro under various pHconditions were also investigated. The results showed that the degradation rates increase with the increase of pH, and at the same time, the degradation rates increase with the increase in sebacic acid content in the copolymers.

Key words: Polymer-controlled drug release systems, Polyesteranhydrides, Melt-polycondensation, Hexestrol

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