高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (6): 895.

• 论文 • 上一篇    下一篇

碳核苷类似物的合成与生物活性

孙德群1, 朱京2, 马灵台2, 张礼和2   

  1. 1. 中国科学院成都有机化学研究所, 成都 610041;
    2. 北京医科大学药学院, 北京 100083
  • 收稿日期:1998-08-04 出版日期:1999-06-24 发布日期:1999-06-24
  • 通讯作者: 孙德群,女,30岁,博士研究生.
  • 作者简介:孙德群,女,30岁,博士研究生.
  • 基金资助:

    国家自然科学基金

Studies on the Syntheses of 3-(β-D-Xylopyranosyl)pyridazine and 3-(β-D-Xylopyranosyl)-4,5-dihydro-1H-6-pyridazinone

SUN De-Qun1, ZU Jing2, MA Ling-Tai2, ZHANG Li-He2   

  1. 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041;
    2. School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083
  • Received:1998-08-04 Online:1999-06-24 Published:1999-06-24

PDF (PC)

被引次数

1

摘要： 利用杂环金属盐法,通过呋喃碳核苷中间体,合成了哒嗪、哒嗪酮等碳核苷,讨论了反应机理;提高了呋喃汞盐法合成碳核苷的收率及立体选择性.

关键词: 呋喃碳核苷, 哒嗪, 哒嗪酮碳核苷

Abstract: New Cnucleoside analogues were synthesized via the key intermediate 2-(2',3'4'-tri-O-benzoyl-β-D-xylopyranosyl)-furan. The stability of the α-and β-isomer was described. The conversion of the furan ring into pyridazine ring was performed by Clauso-Kaas method to give 3-(β-D-xylopyranosyl)pyridazine and 3-(β-D-xylopyranosyl-4,5-dihydro-6(1H)-pyridazinone.

Key words: Pyridazine, Pyridazinone, C-Nucleoside

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