高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (4): 647.

• 论文 • 上一篇    下一篇

中枢神经系统药物树脂制备及其静态交换特性研究

李振华, 皮洪琼, 任广智, 何炳林   

  1. 南开大学高分子化学研究所, 吸附与分离功能高分子材料国家重点实验室, 天津 300071
  • 收稿日期:1998-08-03 出版日期:1999-04-24 发布日期:1999-04-24
  • 通讯作者: 李振华,男,34岁,博士.
  • 作者简介:李振华,男,34岁,博士.
  • 基金资助:

    南开大学吸附与分离功能高分子材料国家重点实验室资助

The Preparation and Exchange Reaction Characteristics of Central Nervous System Drugs-resin Complexes

LI Zhen-Hua, PI Hong-Qiong, REN Guang-Zhi, HE Bing-Lin   

  1. The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, The Institute of Polymer Chemistry, Nankai University, Tianjin, 300071
  • Received:1998-08-03 Online:1999-04-24 Published:1999-04-24

摘要: 以中枢神经系统药物氢溴酸美沙芬(DM)、盐酸伪麻黄碱(PE)、盐酸苯丙醇胺(PM)作为模型药物,以001×7离子交换树脂作为药物载体,在静态条件下,考察了该树脂与上述药物的交换反应动力学和热力学.结果表明,25℃时树脂与DM、PE和PM的反应速率常数k(min-1)分别为1.041×10-3±2.56×10-5,2.290×10-2±1.24×10-4,2.40×10-2±1.02×10-4,且随温度的升高而增加,反应活化能Ea(kJ/mol)分别为50.26,21.68,20.83;在25℃反应达平衡时,表观交换反应平衡常数Ke分别为3.235±0.252,3.680±0.214,4.51±0.328;其自由能变化ΔG°(kJ/mol)分别为-2.909±0.0205,-3.228±0.0181,-3.732±0.0127,表明交换反应是自发的;反应热ΔH°(kJ/mol)分别为88.44±5.548,48.29±3.214,48.66±3.158,即正反应为吸热反应,温度升高有利于向正反应方向进行.

关键词: 氢溴酸美沙芬, 盐酸伪麻黄碱, 盐酸苯丙醇胺, 交换反应动力学, 交换反应热力学

Abstract: In this paper the effect of the chemical structures of various drugs such as dextromethorphan hydrobromide(DM), pseuoephedrine hydrochloride(PE) and phenylpropanolamine hydrochloride(PM) on the exchange behavior with the strongly acidic cation exchanger(0017) was described. From experiments, it indicates that the exchange rate constants were found to be 1.041×10-3±2.56×10-5, 2.290×10-2±1.24×10-4, 2.40×10-2±1.02×10-4min-1at 25℃ respectively. The Keis increased with increasing temperature. The exchange activation energies were calculated to be 50.26, 21.68, 20.83 kJ 5mol-1, respectively. The apparent equilibrium constants(Ke) were calculated to be 3.235±0.252, 3.680±0.214, 4.510±0.328 at 25 , respectively. The exchange reactions are spontaneous according to the data of G=-2.909±0.0205, -3.228±0.0181, -3.732±0.0127 kJ 5mol-1, respectively. The reaction enthalpy H were found to be 88.44±5.548, 48.29±3.214, 48.66±3.158 kJ 5mol-1, respectively, indicating the reaction is enthermal reaction.

Key words: Dextromethorphan hydrobromide, Pseuoephedrine hydrochloride, {Phenylpro-panolamine hydrochloride, Exchange reaction kinetics, Exchange reaction thermodynamics

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