关键词: 酮咯酸, 菲普拉宗, 牛血清蛋白, 人血清蛋白, 荧光猝灭法

Abstract: In this paper, by applying fluorescence quenching method and energy transfer technique, the interaction of serum albumin(BSA and HSA) with ketorolac and feprazone was investigated. The binding sites and binding constants were obtained. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and the main sort of binding force is static-electricity gravitation.

Key words: Ketorolac, Feprazone, BSA, HSA, Fluorescence quenching method