高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 80.

• Organic Synthesis Chemistry • 上一篇    下一篇

Facile Synthesis of (±)-2,6-Dimethethyl-6-hydroxy-2,7-octadienoic Acid and its Methyl Ester and Amide (Acacialactam)

Chusheng Huang1, Xihui Chen3, Ying Li2, Yulin Li2, Hongxing Liu1   

  1. 1. Institute of Applied Chemistry, Guangxi teachers College Nanning 530001;
    2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000;
    3. Department of Chemistry, Guangxi University, Nanning 530004
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 通讯作者: Chusheng Huang E-mail:Chusheng Huang
  • 基金资助:
    Supported by the National Natural Science Foundation of China (No. 29562003) and the Natural Science Foundation of Guangxi Province

Facile Synthesis of (±)-2,6-Dimethethyl-6-hydroxy-2,7-octadienoic Acid and its Methyl Ester and Amide (Acacialactam)

Chusheng Huang1, Xihui Chen3, Ying Li2, Yulin Li2, Hongxing Liu1   

  1. 1. Institute of Applied Chemistry, Guangxi teachers College Nanning 530001;
    2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000;
    3. Department of Chemistry, Guangxi University, Nanning 530004
  • Online:1998-12-31 Published:1998-12-31
  • Contact: Chusheng Huang E-mail:Chusheng Huang
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 29562003) and the Natural Science Foundation of Guangxi Province

摘要: The monoterpenoid acid 1, which is a component of some traditional medicine such as Gymnocladus chinensis baillon in glycoside form,1 was recently isolated from Artemisia sieberi in Iran in free form.2. Its structure has been established to be (E)-2,6-dimethyl-6-hydroxy-2,7-octadienoic acid (1) by chemical and spectroscopic analysis. Its methyl ester derivative 2,was isolated from the antibacterial extracts of the leaves of Piper aduncum3 as well. Acacialactam, a natural product isolated from the seeds of Acacia concinna DC.(Legunninosae) used in folk medicine of several tropical countries for treating some skin diseases, was assigned structure 4 by Sekine et al4 on the basis of its physical and spectral properties.

Abstract: The monoterpenoid acid 1, which is a component of some traditional medicine such as Gymnocladus chinensis baillon in glycoside form,1 was recently isolated from Artemisia sieberi in Iran in free form.2. Its structure has been established to be (E)-2,6-dimethyl-6-hydroxy-2,7-octadienoic acid (1) by chemical and spectroscopic analysis. Its methyl ester derivative 2,was isolated from the antibacterial extracts of the leaves of Piper aduncum3 as well. Acacialactam, a natural product isolated from the seeds of Acacia concinna DC.(Legunninosae) used in folk medicine of several tropical countries for treating some skin diseases, was assigned structure 4 by Sekine et al4 on the basis of its physical and spectral properties.

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