高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 78.
• Organic Synthesis Chemistry • 上一篇 下一篇
Chusheng Huang1, Xihui Chen2, Yulin Li3, Hongxing Liu1
Chusheng Huang1, Xihui Chen2, Yulin Li3, Hongxing Liu1
摘要: Linear 1,7-diarylheptanoids (Ar1-C7-Ar2) are a large group of interesting natural products isolated from plants belonging to Alinia,Curcuma, Zingiber, Alnua,Centridobium and Acer genera used as traditional medicines in some oriental countries1. Pharmacological experiments exhibited that some of them had many physiological actions such as anti-inflammatory, antifungicial, antioxidative,antihepatotoxic activities and so on2. Three natural compounds 13, 24 and 35 (gingerone C) having 1,7-diaryl-4-hepten-3-one skeleton were isolated from the rhizomes of Alpinia offocinarum, the wood of Alnus japonica and the rhizomes of Zingiber officinale respectively. Their structures were elucidated as 1,7-diphenylhept-4-en-3-one(1), 1,7-bis(4-hydroxyphenyl)hept-4-en-3-one(2) and 1-(3-hydroxyl-4-methoxyphenyl)-7-(4-hydroxyphenyl)hept-4-en-3-one(3) by spectral method. Herein, we wish to report facile total synthesis of these three natural compounds. Their synthetic routes were shouwn in scheme.
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