高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 164.

• Organic Synthesis Chemistry • 上一篇    下一篇

First Total Synthesis of (±)-Ponganone Ⅲ

Wenfei Tan1, Erqing Tang1, Chusheng Huang1, Yulin Li1, Wen Cen2, Yacheng Xing2   

  1. 1. National Laboratory of Applied Organic Chemistry and Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, QinDao University, QinDao 266071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This project was financially supported by the Natural Science Foundation of China (29472044)

First Total Synthesis of (±)-Ponganone Ⅲ

Wenfei Tan1, Erqing Tang1, Chusheng Huang1, Yulin Li1, Wen Cen2, Yacheng Xing2   

  1. 1. National Laboratory of Applied Organic Chemistry and Organic Chemistry, Lanzhou University, Lanzhou 730000;
    2. Department of Chemistry, QinDao University, QinDao 266071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This project was financially supported by the Natural Science Foundation of China (29472044)

PDF (PC)

摘要： In recent years, the synthesis and pharmacology of pyranoflavanoids have been extensively investigated due to their wide range of pharmacological properties[1-3]. Ponganone Ⅲ[4],a new natural pyranoflavanone isolated from the Pongamia pinnala, was identified as (2S)-3',4'-dimethoxy-6',6"-dimethylpyrano-[2",3":7,8]-flavanone (2) on the basis of spectra data. Its precursor,3,4-dimethoxy-2'-hydroxy-6",6"-dimethylchromeno-[2",3":4',3']-chalcone (1) is also a new natural product[5] isolated from the roots of Lonchocarpus subglaucescent. Their total synthesis have not been reported. Herein, we wish to report the first total synthesis of compounds 1 and 2 in order to confirm the proposed structure and further more to evaluate its biological activities.

Abstract: In recent years, the synthesis and pharmacology of pyranoflavanoids have been extensively investigated due to their wide range of pharmacological properties[1-3]. Ponganone Ⅲ[4],a new natural pyranoflavanone isolated from the Pongamia pinnala, was identified as (2S)-3',4'-dimethoxy-6',6"-dimethylpyrano-[2",3":7,8]-flavanone (2) on the basis of spectra data. Its precursor,3,4-dimethoxy-2'-hydroxy-6",6"-dimethylchromeno-[2",3":4',3']-chalcone (1) is also a new natural product[5] isolated from the roots of Lonchocarpus subglaucescent. Their total synthesis have not been reported. Herein, we wish to report the first total synthesis of compounds 1 and 2 in order to confirm the proposed structure and further more to evaluate its biological activities.

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