高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 162.

• Organic Synthesis Chemistry • 上一篇    下一篇

First Total Synthesis of (-)-4-O-(6'-Hydroxy-7'(9')-Dehydro-6',7,-Dihydrogeranyl)-Coniferyl Alcohol

Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This work was financially supported by the National Nature Science Foundation of China (Grant NO. 29672015)

First Total Synthesis of (-)-4-O-(6'-Hydroxy-7'(9')-Dehydro-6',7,-Dihydrogeranyl)-Coniferyl Alcohol

Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This work was financially supported by the National Nature Science Foundation of China (Grant NO. 29672015)

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摘要： Some Ligularia species have long used as folk remedies due to their antibiotic, antiphlogistic and antitumor activities.1 Compound 1,2 a novel coniferyl alcohol, was isolated from ligularia duciformis(Compoitae). The geometrical structure of 1,determined by spectroscopic techniques, was corresponded to 4-o-(6,-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl alcohol. But its absolute configuration at C-6,has not yet been determined. Herein, we report the total synthesis of (6'S)-(-)-1 from Geraniol 2 through 9 steps (Scheme 1).

Abstract: Some Ligularia species have long used as folk remedies due to their antibiotic, antiphlogistic and antitumor activities.1 Compound 1,2 a novel coniferyl alcohol, was isolated from ligularia duciformis(Compoitae). The geometrical structure of 1,determined by spectroscopic techniques, was corresponded to 4-o-(6,-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl alcohol. But its absolute configuration at C-6,has not yet been determined. Herein, we report the total synthesis of (6'S)-(-)-1 from Geraniol 2 through 9 steps (Scheme 1).

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