高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (4): 550.

• 论文 • 上一篇    下一篇

维生素B12模型分子侧链钴-氮键稳定性研究

冯亚青1, 张晓东2, 张卫红1   

  1. 1. 天津大学应用化学系, 天津, 300072;
    2. 北洋医药工业研究所, 天津, 300072
  • 收稿日期:1997-05-09 出版日期:1998-04-24 发布日期:1998-04-24
  • 通讯作者: 冯亚青,女,40岁,博士,副教授.
  • 作者简介:冯亚青,女,40岁,博士,副教授.
  • 基金资助:

    国家教育委员会优秀年轻教师基金

Studies of Stability of Co—N Bond on the VB12 Model Molecule

FENG Ya-Qing1, ZHANG Xiao-Dong2, ZHANG Wei-Hong1   

  1. 1. Dept. of Applied Chem., Tianjin University, Tianjin, 300072;
    2. Beiyang Institute of Pharm. Industry, Tianjin University, Tianjin, 300072
  • Received:1997-05-09 Online:1998-04-24 Published:1998-04-24

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摘要： 维生素B12(VB12)模型分子[单腈六甲基-N-(3-咪唑基)丙酰胺钴啉酯高氯酸盐4b-4f],在甲醇溶液中用酸性缓冲溶液处理生成5b-5f.通过测定不同pH的缓冲溶液中的UV-Vis谱,计算了Co-N键的平衡常数,侧链氮原子与中心钴离子配位键的强弱次序为4d＞4f＞4c＞4e＞4b.

关键词: 维生素B12, 模型分子, UV－Vis谱, 平衡常数

Abstract: Vitamin B12 model molecule, dicyano hexamethyl-N-(3-imidazoly)propylamido cobyrinates perchlorate 4b—4f were synthesized and treated with acidic buffers in methanol, and the ring was opened to give compounds 5b—5f. UV-Vis spectra were determined in buffers with different pHvalues, and equilibrium constants of Co—N bonds were calculated. The strength of coordination bonds between Natom in the side chain of cobyrinates and Co atom was in the order of 4d>4f>4c>4e>4b.

Key words: Vitamin B12, Model molecule, UV-Vis spectra, Equilibrium constants

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