高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (3): 477.

• 论文 • 上一篇    下一篇

选择性接聚乙二醇枝聚醚聚酯的合成及其血液相容性

柳春琦, 阮继红, 张鸿志, 冯新德   

  1. 北京大学化学与分子工程学院, 北京, 100871
  • 收稿日期:1996-03-19 出版日期:1997-03-24 发布日期:1997-03-24
  • 通讯作者: 张鸿志.
  • 作者简介:柳春琦, 女, 26岁, 硕士研究生.
  • 基金资助:

    国家自然科学基金

Synthesis of Poly(ether-ester) with PEG Selectively Grafted onto Different Segments and Its Antithrombogenicity

LIU Chun-Qi, RUAN Ji-Hong, ZHANG Hong-Zhi, FENG Xin-De   

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871
  • Received:1996-03-19 Online:1997-03-24 Published:1997-03-24

PDF (PC)

被引次数

10

摘要： 水解α-甲基-ω-(2,3-环氧)丙基聚乙二醇(Ⅱ)得到接有聚乙二醇(PEG)枝的丙二醇(Ⅲ),用其与对苯二甲酰氯及聚丁二醇反应制得在硬链段接有PEG枝的聚醚聚酯(H－PEEs).以四氢呋喃与Ⅱ进行正离子开环共聚合制得每个链接有1.25个PEG枝的聚丁二醇(Ⅳ),用Ⅳ合成了在软链段上接PEG枝的聚醚聚酯(S－PEEs).不同位置接技的PEEs亲水性均较母体明显改进,抗凝血性则以H－PEEs改进显著,其抗凝血复钙时间比本接技者约增长1倍,而S－PEEs改进不明显.

关键词: 聚醚聚酯, 大分子单体, 开环共聚合, 接枝共聚物, 抗凝血性

Abstract: α-Methyl-ω-(2, 3-epoxy)propyl poly (ethylene glycol) (Ⅱ) was hydrolyzed to a glycol (Ⅲ) with a pendent poly (ethylene glycol) (PEG) chaln.Poly (ether-ester) (PEEs)with PEGgrafted ont0 the hard segments (H-PEEs) was synthesized by reacting the glycol (Ⅲ), terephthaloyl chloride and poly (butylene glycol) The macromer (Ⅱ) cationically copolymerized with tetrahydrofuran to give a copolyether (Ⅳ) grafted with PEG.Using copolyether(Ⅳ) having an average 1.25 grafts per molecule, the S-PEEs with PEGgrafted onto soft segments was synthesized.The recalcification time for SuPEEs remalned almost unchanged in comparing with ungrafted PEEs, while that for HuPEEs increased by about 100%, even though the hydrophlcillties both of S-PEEs and H-EEs were ralsed slgniflcantly.

Key words: poly (ether-ester), Macromer, Ring-opening copolymerization, Graft copolymer, Antithrombogenicity

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