BNAH还原质子化N-芳基芴亚胺反应的热力学及机理研究

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (3): 391.

BNAH还原质子化N-芳基芴亚胺反应的热力学及机理研究

鲁云, 刘博, 程津培

南开大学化学系, 天津, 300071

收稿日期:1996-04-17 出版日期:1997-03-24 发布日期:1997-03-24
通讯作者: 程津培.
作者简介:鲁云, 男, 31岁, 博士.
基金资助:
国家自然科学基金;兰州大学应用有机国家重点实验室资助

Mechanism and Energetics of the Reductions of Protonated N-Arylfluroenimine by BNAH

LU Yun, LIU Bo, CHENG Jin-Pei

Department of Chemistry, Nankai University, Tianjin, 300071

Received:1996-04-17 Online:1997-03-24 Published:1997-03-24

摘要/Abstract

摘要： 利用热力学循环方法,通过pK_a和有关电化学数据的测定,首次得到NAD(P)H辅酶模型物(BNAH)按不同机理还原质子化N-芳基芴亚胺的各基元步骤的自由能变化.结合得到的同位素标记结果,从热力学起动力的角度区分了氢负离子的转移机理.

关键词: BNAH, N-芳基芴亚胺, 热力学趋动力, 一步H^-转移机理

Abstract: Free energy changes of each primary steps in one-step hydride transfer and multistep transfer mechanisms in the reductions of protonated N-arylfluorenimines by an NAD (P) Hmodel, BANH, were derived from approprlate thermodynamic cycles by combining PK_a.and relevant electrochemical data, The mechanism of the reduction was proposed as onestep hydride transfer from thermodynamic points of view and the isotope-labelling experiments.

Key words: BNAH, N-Arylfluorenimines, Thermodynamic energetics, One-step hydride transter mechanism

TrendMD:

鲁云, 刘博, 程津培. BNAH还原质子化N-芳基芴亚胺反应的热力学及机理研究. 高等学校化学学报, 1997, 18(3): 391.

LU Yun, LIU Bo, CHENG Jin-Pei. Mechanism and Energetics of the Reductions of Protonated N-Arylfluroenimine by BNAH. Chem. J. Chinese Universities, 1997, 18(3): 391.