高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (1): 37.

• 论文 • 上一篇    下一篇

抗癌药物博莱霉素伏安行为及其反应机理研究

李启隆, 谭学才, 胡劲波   

  1. 北京师范大学化学系, 北京, 100875
  • 收稿日期:1996-01-05 出版日期:1997-01-24 发布日期:1997-01-24
  • 通讯作者: 李启隆.男, 58岁, 教授.
  • 作者简介:李启隆.男, 58岁, 教授.
  • 基金资助:

    国家自然科学基金

Studies on Voltammetric Behaviour and Reaction Mechanism of Bleomycin

LI Qi-Long, TAN Xue-Cai, HU Jin-Bo   

  1. Department of Chemistry Beijing Normal University, Beijing, 100875
  • Received:1996-01-05 Online:1997-01-24 Published:1997-01-24

摘要: 博莱霉素(BLEO)A5在0.05mol/LH2SO4溶液中出现两个还原波,峰电位分别为Ep1=-0.83V和Ep2=1.09V(vs,Ag/AgCI)用线性扫描与循环伏安法、恒电位库仑法、脉冲极谱、交流极借等手段研究体系的伏安行为及反应机理.实验表明,P1为BLEOA5分子中嘧啶环第一步两电子还原的吸附波,P2为嘧啶环第二、三步还原和催化氢还原的具有吸附性的重叠波.

关键词: 博莱霉素, 伏安行为, 吸附波, 催化氢波

Abstract: In 0.05mol/L H2SO4 solution, two reductive peaks P1 and P2 of bleomycin A5were obtained.The peak potentials Ep1, and Ep2 are -0.83 Vand - 1.09 V(vs., Ag/AgCl),respectively.The voltammetrlc behaviour and reaction mechanism of bleomycin A5, have been studied by means of linear sweep and cyclic voltammetry, NPP, ACpolarography and UVspectrophotometry.The experiments have proved that P1 is irreversible adsorption wave,which involves two electrons process for the reduction of 3, 4(N = C) group in pyrimidine cyclic of bleomycin A5.P2 is also the irreversible adsorption wave, which involves further re-duction of pyrimidine cycle and catalyt1c hydrogen wave.

Key words: Bleomycin, Voltammetric behaviour, Adsorptive wave, Catalytic hydrogen wave

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