高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (S1): 116.

• 研究论文 • 上一篇    下一篇

Liposomes Prepared from Inverse Micelles

LU Zu-hong, WU Yijuan, Zhang Bao   

  1. National Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing, 210096, P. R. China
  • 收稿日期:1995-08-27 出版日期:1995-12-31 发布日期:1995-12-31
  • 基金资助:

    National Natural Science Foundation of China

Liposomes Prepared from Inverse Micelles

LU Zu-hong, WU Yijuan, Zhang Bao   

  1. National Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing, 210096, P. R. China
  • Received:1995-08-27 Online:1995-12-31 Published:1995-12-31
  • Supported by:

    National Natural Science Foundation of China

PDF (PC)

摘要：

A method for the preparation of liposome is introduced, which contains two experimental steps: (a) inverse micelles of lecithin are formed in water-in-oil system by sonication; (b) the micelles are spread on the water surface, passed Through the oil-water interface, and transformed into liposomes in the water phase. The main advantage of this method is that the inner aqueous solution encapsulated by liposomes could be different from their enviromental medium. The liposome size is less than 0.5 μm in diameter by atomic force microscope. Comparison of activities of urease with and without liposome encapsulation suggested that urease was well entraped into liposomes.

关键词: Inverse micell, Liposome, Oil-water interface, AFM

Abstract:

A method for the preparation of liposome is introduced, which contains two experimental steps: (a) inverse micelles of lecithin are formed in water-in-oil system by sonication; (b) the micelles are spread on the water surface, passed Through the oil-water interface, and transformed into liposomes in the water phase. The main advantage of this method is that the inner aqueous solution encapsulated by liposomes could be different from their enviromental medium. The liposome size is less than 0.5 μm in diameter by atomic force microscope. Comparison of activities of urease with and without liposome encapsulation suggested that urease was well entraped into liposomes.

Key words: Inverse micell, Liposome, Oil-water interface, AFM

TrendMD: