高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (9): 1420.

• 研究简报 • 上一篇    下一篇

藁本内醋和(±)-芹菜乙素的合成研究

李绍白, 张少明, 李裕林   

  1. 兰州大学应用有机化学国家重点实验室, 有机化学研究所, 兰州, 730000
  • 收稿日期:1994-08-25 修回日期:1995-05-24 出版日期:1995-09-24 发布日期:1995-09-24
  • 通讯作者: 李绍白,男,48岁,副研究员.
  • 作者简介:李绍白,男,48岁,副研究员.
  • 基金资助:

    国家自然科学基金

Study of Syntheses of Ligustilid and (±)-Sedenenolide

LI Shao-Bai, ZHANG Shao-Ming, LI Yu-Lin   

  1. State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1994-08-25 Revised:1995-05-24 Online:1995-09-24 Published:1995-09-24

PDF (PC)

关键词: 藁本内酯, 芹菜乙素, 3Z-正丁烯基苯酞

Abstract: Z-Ligustilide (1) and sedenenolide (2)are important naturally 3-alkylphthalide analogues occurring in many plants belonging to the Umbelliferae.They have antispasmodic antiasthmatic and smooth muscle relaxing activities.Herein the synthesis of(±)-sedenenolide (2) is described,starting from phthlic anhydride as starting material,The key step in the synthesis is the Birch reduction of 3Z-butylidenephthalide, 3-methyloxy-3-butylphthalide (4)and methyl o-valerybenzoate(3).The yield in this step is 44%-60%. The synthesis of ligustilide (1) was studied.

Key words: Ligustilide, Sedenenolide, 3Z-Butylidenephthalide

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