高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (8): 1254.

• 论文 • 上一篇    下一篇

γ-[N1-取代-1,4,5,6-四氢(及1,6-二氢)-6-氧-3-哒嗪酰胺基]丁酸乙酯类化合物的合成

许凤荣, 王书玉, 徐萍, 黎辉, 胡长风, 欧阳荔   

  1. 北京医科大学药学院
  • 出版日期:1995-08-24 发布日期:1995-08-24

Synthesis of Ethyl Esters of γ-[N1-Substituted-1,4,5,6-tetrahydro(or 1,6-dihydro)-6-oxo-3-pyridazinamide]butyric Acid

XU Feng-Rong, WANG Shu-Yu, XU Ping, LI Hui, HU Chang-Feng, OUYANG Li   

  1. School of Pharmaceutical Sciences, Analysis and Computation Center, Beijing Medical University, Beijing, 100083
  • Online:1995-08-24 Published:1995-08-24

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关键词: 6-氧-3-哒嗪酸, 哒嗪类衍生物, 相转移催化反应(PTC)

Abstract: Tetrahydro-6-oxo-3-pyridazinecarboxylic acid(I) was obtained by the condensate of α-oxoglutaric acid with hydrazine hydrate.Iwas dehydrogenated to give 1,6dihydro-6-oxo-3-pyridazinecarboxylic acid(Ⅱ).Under the phase transfer catalysis,Ⅲ and Ⅳwere converted into corresponding N1-substituted-1,4,5,6-tetrahydro-6-oxo-3-pyridazinecarboxylic acids(Ⅴ)and N1-substituted-1,6-dihydro-6-oxo-3-pyridazinecarboxylic acids(Ⅵ),which then condensated with ethyl ester of γ-amino butyric acid.Ten ethyl esters of γ-[N1-substituted-1,4,5,6-tetrahydro(or 1,6-dihydro)-6-oxo-3-pyridazinamide]butyric acid(Ⅶa c and Ⅷa e)were synthesized. All compounds synthesized here have not been found in the literature.

Key words: xo-3-pyridazinecarboxylic acid, Derivatives of pyridazine, Phase transfer catalysis reaction(PTC)

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