高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (6): 915.

• 研究快报 • 上一篇    下一篇

含有手性甲基膦酸酯基的十一聚核糖核苷酸的合成

周英姿, 王来新, 张礼和   

  1. 北京医科大学天然药物及仿生药物国家重点实验室, 北京, 100083
  • 收稿日期:1995-01-03 修回日期:1995-03-20 出版日期:1995-06-24 发布日期:1995-06-24
  • 通讯作者: 张礼和
  • 作者简介:周英姿,女,31岁,助教.
  • 基金资助:

    国家自然科学基金

Synthesis of Ribozyme Substrates Containing Chiral Methylphosphonate at Cleavage Site

ZHOU Ying-Zi, WANG Lai-Xin, ZHANG Li-He   

  1. State Key Laboratory of Natural and Biominietic Medicine, Beijing Medical University, Beijing, 100083
  • Received:1995-01-03 Revised:1995-03-20 Online:1995-06-24 Published:1995-06-24

PDF (PC)

关键词: 酶性核酸, 3', 5'-二胞嘧啶核苷甲基膦酸酯, 立体化学, 手性底物

Abstract: Two stereoisomers of dicytidylyl methylphosphonate 10 and 11 were synthesized and used as a block for the synthesis of ribozyme substrates containing chiral center at the cleavage site.

Key words: Ribozyme, Dicytidylyl methylphosphonate, Stereochemistry, Chiral substrate

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