高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (10): 1633.

• 论文 • 上一篇    下一篇

交联聚磷酸酯的合成及其释药性能研究

罗毅1, 卓仁禧2, 范昌烈2   

  1. 1. 北京大学化学系, 北京, 100871;
    2. 武汉大学化学系, 武汉, 430072
  • 收稿日期:1994-10-14 修回日期:1995-02-21 出版日期:1995-10-24 发布日期:1995-10-24
  • 通讯作者: 卓仁禧
  • 作者简介:罗毅,男,24岁,博士后.
  • 基金资助:

    国家自然科学基金

Synthesis of Crosslinked Polyphosphates and Drug Release

LUO Yi1, ZHUO Ren-xi2, FAN Chang-Lie2   

  1. 1. Department of Chemistry, Peking University, Beijing, 100871;
    2. Department of Chemistry, Wuhan University, 430072
  • Received:1994-10-14 Revised:1995-02-21 Online:1995-10-24 Published:1995-10-24

PDF (PC)

被引次数

16

摘要： 以(i-Bu)3Al为引发剂研究了2-氢-氧-1,3,2-二氧五环磷酸酯,2-氢-2-氧-1,3,2-二氧六环磷酸酯的开环均聚和共聚合反应,然后经过氯化、水解获得了交联聚磷酸酯材料。以合成的交联聚磷酸酯为药物载体,采用单层骨架片、双层骨架片和夹心片的载药方式,对抗肿瘤药物5-氟尿嘧啶进行了控制释放,获得了较好的释药效果。

关键词: 交联聚磷酸酯, 5-氟尿嘧啶, 控制释放

Abstract: Ring-opening polymerizations of 2-hydro-2-oxo-3,2-dioxa-phospholan and/or 2-hydro-2-oxo-1,3,2-dioxaphosphorinane were studied using(i-Bu3)Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained.The in vitro release of 5-fluorouracil from its single-matrix pellets,double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out in phosphate buffer solution(pH7.4)at 37℃. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.

Key words: Crosslinked polyphosphate, 5-Fluorouracil, Drug release

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