高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (12): 1807.

• 研究简报 • 上一篇    下一篇

对氨基苯甲酸酯同系物与细胞色素P450代谢中间体络合物形成速率的定量构效关系

傅旭春, 刘志强, 蒋惠娣   

  1. 浙江医科大学药学系, 杭州, 310006
  • 收稿日期:1993-12-24 修回日期:1994-04-21 出版日期:1994-12-24 发布日期:1994-12-24
  • 通讯作者: 傅旭春,男,33岁 .硕士.讲师.
  • 作者简介:傅旭春,男,33岁 .硕士.讲师.
  • 基金资助:

    国家自然科学基金;中国医学科学院青年科学基金

Quantiative Structure-Activity Relationship Between p-Aminobenzoates and Formation Rate of Cytochrome P450 Metabolic Intermediate Complex

FU Xu-Chun, LIU Zhi-Qiang, JIANG Hui-Di   

  1. Department of Pharmacy, Zhejiang Medical University, Hangzhou, 310006
  • Received:1993-12-24 Revised:1994-04-21 Online:1994-12-24 Published:1994-12-24

PDF (PC)

关键词: 细胞色素P450, 对氨基苯甲酸酯, 代谢中间体络合物, 定量构效关系, 分子连接性

Abstract: The formation rates (v) of cytochrome P450 metabolic intermediate complexes for twelve p-aminobenzoates with untreated or phenobarbital pretreated rat hepatic microsomes were tested. both Hansch's method and molecular connectivity method were used to establish their quantitative structure-activity relationship equations. The significant parabolic correlations between the logarithm values of the formation rates (lgv) and the logarithm values of octanol/water partition coefficients of the p-aminobenzoates (lgP) or their first-order valence molecular connectivity indexes (1χν) were observed.

Key words: Cytochrome P450, p-Aminobenzoates, Metabolic intermediate complex, Quantitative structure-activity relationship, Molecular connectivity

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