高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (10): 1484.

• 论文 • 上一篇    下一篇

分子内反应与分子内催化(Ⅳ)─羟基诱导效应对分子内苯并咪唑基一般碱催化3－(2'－苯并咪唑基)－3－羟基丙酸乙酯水解的影响

夏道宏1, 夏炽中2   

  1. 1. 东营石油大学化学工程系, 东营, 257062;
    2. 山西大学分子科学研究所, 太原
  • 收稿日期:1993-11-24 修回日期:1994-03-05 出版日期:1994-10-24 发布日期:1994-10-24
  • 通讯作者: 夏道宏,男,30岁,博士研究生,讲师.
  • 作者简介:夏道宏,男,30岁,博士研究生,讲师.
  • 基金资助:

    国家自然科学基金

Intramolecular Reaction and Intramolecular Catalysis(Ⅳ)─Inductive Effect of Hydroxy Group on the Intramolecular General-base Catalyzed Hydrolysis of Ethyl 3-(2'-benzimidazolyl)-3-hydroxy Propionate by Benzimidazolyl Group

XIA Dao-Hong1, XIA Chi-Zhong2   

  1. 1. Department of Chemical Engineering, Petroleum University, Dongying, 257062;
    2. Institute of Molecular Science, Shanxi University, Taiyuan
  • Received:1993-11-24 Revised:1994-03-05 Online:1994-10-24 Published:1994-10-24

PDF (PC)

摘要： 在3-(2'-苯并咪唑基)-3-羟基丙酸乙酯水解过程中,苯并咪唑基以分子内一般碱催化方式参与催化酯的水解反应。分子内羟基的存在,虽然没有改变苯并咪唑基的催化方式,但对其催化活性具有明显的影响。从分子内羟基的诱导效应以及氢键的形成对实验结果进行了讨论。

关键词: 分子内催化, 一般碱催化, 诱导效应, 酯水解反应

Abstract: Benzimidazolyl group exhibits catalytic activity in the way as intramolecular general-base catalysis in the hydrolysis of 3-(2'-benzimidazolyl)-3-hydroxy propionate. Although the presence of hydroxy group in the molecule didn't change the catalytic way of benzimidazolyl group, but affected its catalytic activity evidently, Discussion for the experimental results in view of inductive effect and hydrogen bond of hydroxy group is presented.

Key words: Intramolecular catalysis, General-base catalysis, Inductive effect, Ester hydrolysis reaction

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